| 9/2/2021 | Bowling Green (4-8) | 6 | at | Tennessee | 38 | MAC | ||
| 9/11/2021 | Pittsburgh (11-3) | 41 | at | Tennessee | 34 | ACC | ||
| 9/18/2021 | Tennessee Tech (3-8) | 0 | at | Tennessee | 56 | OVC (1AA) | ||
| 9/25/2021 | Tennessee | 14 | at | Florida (6-7,2-6) | 38 | |||
| 10/2/2021 | Tennessee | 62 | at | Missouri (6-7,3-5) | 24 | |||
| 10/9/2021 | South Carolina (7-6,3-5) | 20 | at | Tennessee | 45 | |||
| 10/16/2021 | Mississippi (10-3,6-2) | 31 | at | Tennessee | 26 | |||
| 10/23/2021 | Tennessee | 24 | at | Alabama (13-2,8-2) | 52 | |||
| 11/6/2021 | Tennessee | 45 | at | Kentucky (10-3,5-3) | 42 | |||
| 11/13/2021 | Georgia (14-1,9-1) | 41 | at | Tennessee | 17 | |||
| 11/20/2021 | South Alabama (5-7) | 14 | at | Tennessee | 60 | SBC | ||
| 11/27/2021 | Vanderbilt (2-10,0-8) | 21 | at | Tennessee | 45 | |||
| 12/30/2021 | Tennessee | 45 | vs | Purdue (9-4) | 48 | OT | Music City Bowl - Nashville TN | vs B10 |
| vs Tennessee | vs Other Opponents | Tennessee compared to OOs | |
| Record: | 6-7 | 94-62 | |
| Points Scored: | 29.08 | 29.70 | 0.62 |
| Points Allowed: | 39.31 | 23.94 | 15.37 |
| Margin: | -10.23 | 5.76 | 15.99 |
| Total Points: | 68.39 | 53.64 | 14.75 |