| 9/2/2021 | Millsaps | 28 | at | Belhaven | 56 | @ ASWC | ||
| 9/4/2021 | Hendrix | at | Austin | Canceled COVID | ||||
| Maryville | 14 | at | Berry | 20 | USASC | |||
| LaGrange | 17 | at | Birmingham-Southern | 42 | USASC | |||
| Hanover | 34 | at | Centre | 56 | HCA | |||
| Augustana IL | 31 | at | Rhodes | 21 | CCIW | |||
| Sewanee | at | St Scholastica | Canceled COVID | @ MIA | ||||
| McMurry | at | Trinity TX | Canceled COVID | ASWC | ||||
| 9/11/2021 | Rhodes | 29 | at | Franklin | 36 | @ HCA | ||
| Wisconsin-River Falls | 49 | at | Hendrix | 33 | WIAC | |||
| Birmingham-Southern | 48 | at | Huntingdon AL | 9 | @ USASC | |||
| Berry | 34 | at | LaGrange | 21 | @ USASC | |||
| Centre | 40 | at | Maryville | 21 | @ USASC | |||
| Austin | 7 | at | Texas Lutheran | 41 | @ ASWC | |||
| Macalester | 0 | at | Trinity TX | 64 | MIA | |||
| Sewanee | 0 | at | Washington and Lee | 52 | @ ODC | |||
| 9/18/2021 | Birmingham-Southern | 55 | at | Arkansas Baptist | 6 | @ None (Unk?) | ||
| Sul Ross State | 7 | at | Austin | 16 | ASWC | |||
| Hendrix | 21 | vs | Howard Payne | 55 | Prosper TX | vs ASWC | ||
| Westminster MO | 30 | at | Sewanee | 29 | UMWAC | |||
| Millsaps | 21 | at | Southwestern Assemblies of God | 38 | @ Soon (NAIA) | |||
| Trinity TX | 51 | at | Texas Lutheran | 14 | @ ASWC | |||
| Berry | 7 | at | Wisconsin-Whitewater | 39 | @ WIAC | |||
| 9/25/2021 | Austin | 14 | at | Belhaven | 41 | @ ASWC | ||
| Trine | 7 | at | Centre | 14 | MIAA | |||
| Sewanee | 27 | at | Hendrix | 49 | ||||
| Olivet | 44 | at | Millsaps | 27 | MIAA | |||
| Rhodes | 47 | at | Westminster MO | 7 | @ UMWAC | |||
| 10/2/2021 | Mary Hardin-Baylor | 56 | at | Austin | 0 | ASWC | ||
| Trinity TX | 27 | at | Berry | 6 | ||||
| Sewanee | 0 | at | Birmingham-Southern | 49 | ||||
| Hendrix | 21 | at | Centre | 42 | ||||
| Millsaps | 42 | at | Rhodes | 21 | ||||
| 10/9/2021 | Birmingham-Southern | 43 | at | Hendrix | 6 | |||
| Berry | 49 | at | Millsaps | 21 | ||||
| Rhodes | 55 | at | Sewanee | 13 | ||||
| Centre | 7 | at | Trinity TX | 27 | ||||
| 10/16/2021 | Sewanee | 0 | at | Berry | 59 | |||
| Birmingham-Southern | 28 | at | Centre | 21 | ||||
| Austin | 13 | at | McMurry | 48 | @ ASWC | |||
| Hendrix | 13 | at | Rhodes | 16 | 2OT | |||
| Millsaps | 0 | at | Trinity TX | 46 | ||||
| 10/23/2021 | East Texas Baptist | 37 | at | Austin | 30 | ASWC | ||
| Rhodes | 6 | at | Birmingham-Southern | 41 | ||||
| Berry | 42 | at | Hendrix | 21 | ||||
| Centre | 66 | at | Millsaps | 34 | ||||
| Trinity TX | 66 | at | Sewanee | 7 | ||||
| 10/30/2021 | Birmingham-Southern | 21 | at | Berry | 3 | |||
| Rhodes | 6 | at | Centre | 49 | ||||
| Sewanee | 32 | at | Millsaps | 42 | ||||
| Austin | 19 | at | Southwestern Texas | 45 | @ ASWC | |||
| Hendrix | 13 | at | Trinity TX | 62 | ||||
| 11/6/2021 | Hardin-Simmons | 56 | at | Austin | 14 | ASWC | ||
| Trinity TX | 28 | at | Birmingham-Southern | 27 | ||||
| Millsaps | 7 | vs | Hendrix | 34 | Little Rock AR | |||
| Berry | 45 | at | Rhodes | 14 | ||||
| Centre | 30 | at | Sewanee | 20 | ||||
| 11/13/2021 | Centre | 49 | at | Berry | 27 | |||
| Austin | 21 | at | Howard Payne | 49 | @ ASWC | |||
| Birmingham-Southern | 49 | at | Millsaps | 7 | ||||
| Hendrix | 56 | at | Sewanee | 10 | ||||
| Rhodes | 21 | at | Trinity TX | 55 | ||||
| 11/20/2021 | Huntingdon AL | 14 | at | Birmingham-Southern | 24 | USASC | ||
| Trinity TX | 3 | at | Mary Hardin-Baylor | 13 | @ ASWC | |||
| 11/27/2021 | Birmingham-Southern | 7 | at | Mary Hardin-Baylor | 42 | @ ASWC |