| 9/4/2021 | Southwestern Assemblies of God | 20 | at | Louisiana College (4-7,4-5) | 13 | |||
| 9/11/2021 | Ottawa AZ (8-2,8-1) | 42 | at | Southwestern Assemblies of God | 28 | |||
| 9/18/2021 | Millsaps (2-8) | 21 | at | Southwestern Assemblies of God | 38 | SAA (D3) | ||
| 9/25/2021 | Southwestern Assemblies of God | 45 | at | Arizona Christian (8-2,7-2) | 52 | |||
| 10/2/2021 | Arkansas Baptist (0-7) | 6 | at | Southwestern Assemblies of God | 50 | None (Unk?) | ||
| 10/9/2021 | Texas Wesleyan (7-3,7-2) | 38 | at | Southwestern Assemblies of God | 33 | |||
| 10/16/2021 | Southwestern Assemblies of God | 48 | at | Panhandle State (4-7,3-6) | 6 | |||
| 10/23/2021 | Lyon (2-8,2-7) | 21 | at | Southwestern Assemblies of God | 38 | |||
| 10/30/2021 | Wayland Baptist (2-8,2-7) | 29 | at | Southwestern Assemblies of God | 54 | |||
| 11/6/2021 | Southwestern Assemblies of God | 63 | at | Texas College (0-11,0-9) | 0 | |||
| 11/13/2021 | Southwestern Assemblies of God | 41 | at | Langston (7-3,6-3) | 24 | |||
| 11/20/2021 | Sterling (6-6) | 14 | at | Southwestern Assemblies of God | 31 | KCAC |
| vs Southwestern Assemblies of God | vs Other Opponents | Southwestern Assemblies of God compared to OOs | |
| Record: | 3-9 | 47-63 | |
| Points Scored: | 22.17 | 29.63 | 7.46 |
| Points Allowed: | 40.75 | 36.02 | 4.73 |
| Margin: | -18.58 | -6.39 | 12.19 |
| Total Points: | 62.92 | 65.65 | -2.73 |