| 9/4/2021 | Franklin | 35 | at | Illinois Wesleyan (3-7) | 21 | at CCIW | ||
| 9/11/2021 | Rhodes (3-7) | 29 | at | Franklin | 36 | SAA | ||
| 9/18/2021 | Wisconsin-Platteville (4-6) | 44 | at | Franklin | 19 | WIAC | ||
| 10/2/2021 | Manchester (3-7,3-4) | 27 | at | Franklin | 24 | OT | ||
| 10/9/2021 | Franklin | 14 | at | Mt St Joseph (6-4,5-2) | 28 | |||
| 10/16/2021 | Bluffton (4-6,3-4) | 6 | at | Franklin | 45 | |||
| 10/23/2021 | Franklin | 17 | at | Anderson (1-9,1-6) | 0 | |||
| 10/30/2021 | Franklin | 13 | at | Defiance (1-9,1-6) | 7 | |||
| 11/6/2021 | Rose-Hulman (8-3,7-0) | 38 | at | Franklin | 14 | |||
| 11/13/2021 | Franklin | 27 | at | Hanover (5-5,4-3) | 16 |
| vs Franklin | vs Other Opponents | Franklin compared to OOs | |
| Record: | 4-6 | 34-57 | |
| Points Scored: | 21.60 | 23.68 | 2.08 |
| Points Allowed: | 24.40 | 29.85 | -5.45 |
| Margin: | -2.80 | -6.17 | -3.37 |
| Total Points: | 46.00 | 53.53 | -7.53 |