| 9/2/2021 | Trine | 52 | at | Manchester (3-7) | 14 | at HCA | ||
| 9/11/2021 | Rose-Hulman (8-3) | 31 | at | Trine | 30 | HCA | ||
| 9/18/2021 | Mt St Joseph (6-4) | 30 | at | Trine | 31 | OT | HCA | |
| 9/25/2021 | Trine | 7 | at | Centre (8-2) | 14 | at SAA | ||
| 10/2/2021 | Adrian (5-5,4-3) | 20 | at | Trine | 36 | |||
| 10/9/2021 | Trine | 35 | at | Olivet (7-3,4-3) | 14 | |||
| 10/23/2021 | Kalamazoo (1-9,0-6) | 13 | at | Trine | 47 | |||
| 10/30/2021 | Trine | 24 | at | Albion (9-2,5-1) | 31 | |||
| 11/6/2021 | Trine | 37 | at | Alma (5-5,1-5) | 23 | |||
| 11/13/2021 | Hope (8-2,5-1) | 17 | at | Trine | 13 |
| vs Trine | vs Other Opponents | Trine compared to OOs | |
| Record: | 4-6 | 56-36 | |
| Points Scored: | 20.70 | 29.68 | 8.98 |
| Points Allowed: | 31.20 | 23.01 | 8.19 |
| Margin: | -10.50 | 6.67 | 17.17 |
| Total Points: | 51.90 | 52.69 | -0.79 |