| 9/4/2021 | Wayland Baptist (2-8) | 0 | at | Hardin-Simmons | 49 | Soon (NAIA) | ||
| 9/11/2021 | Hardin-Simmons | 27 | at | Sul Ross State (2-8,2-6) | 0 | |||
| 9/18/2021 | Belhaven (7-3,5-3) | 16 | at | Hardin-Simmons | 21 | |||
| 9/25/2021 | Hardin-Simmons | 28 | at | Mary Hardin-Baylor (15-0,8-0) | 34 | |||
| 10/2/2021 | McMurry (2-7,1-7) | 21 | at | Hardin-Simmons | 24 | |||
| 10/16/2021 | Hardin-Simmons | 34 | at | East Texas Baptist (5-5,3-5) | 0 | |||
| 10/23/2021 | Southwestern Texas (4-6,3-5) | 7 | at | Hardin-Simmons | 69 | |||
| 10/30/2021 | Hardin-Simmons | 38 | at | Howard Payne (7-3,5-3) | 14 | |||
| 11/6/2021 | Hardin-Simmons | 56 | at | Austin (1-8) | 14 | at SAA | ||
| 11/13/2021 | Texas Lutheran (3-7,2-6) | 0 | at | Hardin-Simmons | 65 |
| vs Hardin-Simmons | vs Other Opponents | Hardin-Simmons compared to OOs | |
| Record: | 1-9 | 47-46 | |
| Points Scored: | 10.60 | 28.73 | 18.13 |
| Points Allowed: | 41.10 | 28.45 | 12.65 |
| Margin: | -30.50 | 0.28 | 30.78 |
| Total Points: | 51.70 | 57.18 | -5.48 |