| 9/4/2021 | Wisconsin-Oshkosh (6-3) | 28 | at | Huntingdon AL | 24 | WIAC | ||
| 9/11/2021 | Birmingham-Southern (10-2) | 48 | at | Huntingdon AL | 9 | SAA | ||
| 9/25/2021 | Huntingdon AL | 21 | at | Brevard (6-4,4-2) | 14 | |||
| 10/2/2021 | Methodist (7-2,5-1) | 21 | at | Huntingdon AL | 48 | |||
| 10/9/2021 | Huntingdon AL | 48 | at | Southern Virginia (2-8) | 20 | at ODC | ||
| 10/16/2021 | Averett (5-5) | 25 | at | Huntingdon AL | 30 | ODC | ||
| 10/23/2021 | Huntingdon AL | 42 | at | Greensboro (0-10,0-6) | 3 | |||
| 10/30/2021 | North Carolina Wesleyan (4-6,2-4) | 7 | at | Huntingdon AL | 30 | |||
| 11/6/2021 | Maryville (4-6,3-3) | 33 | at | Huntingdon AL | 52 | |||
| 11/13/2021 | Huntingdon AL | 55 | at | LaGrange (2-8,1-5) | 9 | |||
| 11/20/2021 | Huntingdon AL | 14 | at | Birmingham-Southern (10-2) | 24 | at SAA |
| vs Huntingdon AL | vs Other Opponents | Huntingdon AL compared to OOs | |
| Record: | 3-8 | 51-48 | |
| Points Scored: | 21.09 | 27.10 | 6.01 |
| Points Allowed: | 33.91 | 23.30 | 10.61 |
| Margin: | -12.82 | 3.80 | 16.62 |
| Total Points: | 55.00 | 50.40 | 4.60 |