| 9/4/2021 | Hanover | 34 | at | Centre (8-2) | 56 | at SAA | ||
| 9/11/2021 | Adrian (5-5) | 14 | at | Hanover | 21 | MIAA | ||
| 9/18/2021 | Hanover | 14 | at | Albion (9-2) | 24 | at MIAA | ||
| 10/2/2021 | Anderson (1-9,1-6) | 0 | at | Hanover | 49 | |||
| 10/9/2021 | Hanover | 21 | at | Rose-Hulman (8-3,7-0) | 31 | |||
| 10/16/2021 | Defiance (1-9,1-6) | 0 | at | Hanover | 51 | |||
| 10/23/2021 | Hanover | 41 | at | Bluffton (4-6,3-4) | 10 | |||
| 10/30/2021 | Manchester (3-7,3-4) | 0 | at | Hanover | 33 | |||
| 11/6/2021 | Hanover | 6 | at | Mt St Joseph (6-4,5-2) | 23 | |||
| 11/13/2021 | Franklin (6-4,4-3) | 27 | at | Hanover | 16 |
| vs Hanover | vs Other Opponents | Hanover compared to OOs | |
| Record: | 5-5 | 46-46 | |
| Points Scored: | 18.50 | 25.36 | 6.86 |
| Points Allowed: | 28.60 | 26.09 | 2.51 |
| Margin: | -10.10 | -0.73 | 9.37 |
| Total Points: | 47.10 | 51.45 | -4.35 |