| 9/4/2021 | Maryville | 14 | at | Berry (6-4) | 20 | at SAA | ||
| 9/11/2021 | Centre (8-2) | 40 | at | Maryville | 21 | SAA | ||
| 9/18/2021 | Methodist (7-2,5-1) | 38 | at | Maryville | 21 | |||
| 9/25/2021 | Maryville | 10 | at | Averett (5-5) | 47 | at ODC | ||
| 10/2/2021 | Southern Virginia (2-8) | 17 | at | Maryville | 38 | ODC | ||
| 10/9/2021 | Maryville | 0 | at | Brevard (6-4,4-2) | 31 | |||
| 10/16/2021 | Maryville | 31 | at | North Carolina Wesleyan (4-6,2-4) | 26 | |||
| 10/23/2021 | LaGrange (2-8,1-5) | 16 | at | Maryville | 52 | |||
| 11/6/2021 | Maryville | 33 | at | Huntingdon AL (8-3,6-0) | 52 | |||
| 11/13/2021 | Greensboro (0-10,0-6) | 14 | at | Maryville | 49 |
| vs Maryville | vs Other Opponents | Maryville compared to OOs | |
| Record: | 6-4 | 42-48 | |
| Points Scored: | 30.10 | 24.71 | -5.39 |
| Points Allowed: | 26.90 | 24.84 | 2.06 |
| Margin: | 3.20 | -0.13 | -3.33 |
| Total Points: | 57.00 | 49.55 | 7.45 |