| 9/4/2021 | Texas Lutheran (3-7,2-6) | 17 | at | Howard Payne | 43 | |||
| 9/11/2021 | Howard Payne | 42 | at | McMurry (2-7,1-7) | 36 | |||
| 9/18/2021 | Hendrix (3-7) | 21 | vs | Howard Payne | 55 | Prosper TX | SAA | |
| 9/25/2021 | Howard Payne | 49 | at | East Texas Baptist (5-5,3-5) | 38 | |||
| 10/2/2021 | Sul Ross State (2-8,2-6) | 30 | at | Howard Payne | 73 | |||
| 10/16/2021 | Howard Payne | 21 | at | Southwestern Texas (4-6,3-5) | 17 | |||
| 10/23/2021 | Belhaven (7-3,5-3) | 24 | at | Howard Payne | 10 | |||
| 10/30/2021 | Hardin-Simmons (9-1,7-1) | 38 | at | Howard Payne | 14 | |||
| 11/6/2021 | Howard Payne | 14 | at | Mary Hardin-Baylor (15-0,8-0) | 59 | |||
| 11/13/2021 | Austin (1-8) | 21 | at | Howard Payne | 49 | SAA |
| vs Howard Payne | vs Other Opponents | Howard Payne compared to OOs | |
| Record: | 3-7 | 48-45 | |
| Points Scored: | 30.10 | 27.92 | -2.18 |
| Points Allowed: | 37.00 | 26.26 | 10.74 |
| Margin: | -6.90 | 1.66 | 8.56 |
| Total Points: | 67.10 | 54.18 | 12.92 |