| 9/4/2021 | Washington and Lee | 24 | at | Christopher Newport (5-5) | 28 | at NJAC | ||
| 9/11/2021 | Sewanee (0-10) | 0 | at | Washington and Lee | 52 | SAA | ||
| 9/18/2021 | Guilford (1-7,0-6) | 7 | at | Washington and Lee | 63 | |||
| 9/25/2021 | Washington and Lee | 25 | at | Randolph-Macon (9-1,5-1) | 24 | |||
| 10/2/2021 | Washington and Lee | 32 | at | Hampden-Sydney (5-5,4-2) | 30 | |||
| 10/9/2021 | Apprentice (1-7) | 13 | at | Washington and Lee | 42 | None (Unk?) | ||
| 10/23/2021 | Bridgewater VA (4-6,2-5) | 0 | at | Washington and Lee | 17 | |||
| 10/30/2021 | Washington and Lee | 30 | at | Emory & Henry (6-4) | 28 | at D2Ind | ||
| 11/6/2021 | Ferrum (6-4,4-3) | 24 | at | Washington and Lee | 28 | |||
| 11/13/2021 | Washington and Lee | 6 | at | Shenandoah (7-3,3-3) | 14 | |||
| 11/20/2021 | Washington and Lee | 0 | at | Mount Union (13-1) | 52 | at OAC |
| vs Washington and Lee | vs Other Opponents | Washington and Lee compared to OOs | |
| Record: | 3-8 | 54-45 | |
| Points Scored: | 20.00 | 29.09 | 9.09 |
| Points Allowed: | 29.00 | 27.03 | 1.97 |
| Margin: | -9.00 | 2.06 | 11.06 |
| Total Points: | 49.00 | 56.12 | -7.12 |