| 9/4/2021 | Southwestern Texas | 7 | at | Cal Lutheran (5-3) | 37 | at SCIAC | ||
| 9/11/2021 | Southwestern Texas | 34 | at | Belhaven (7-3,5-3) | 27 | |||
| 9/18/2021 | Mary Hardin-Baylor (15-0,8-0) | 54 | at | Southwestern Texas | 3 | |||
| 9/25/2021 | Southwestern Texas | 31 | at | McMurry (2-7,1-7) | 41 | |||
| 10/2/2021 | East Texas Baptist (5-5,3-5) | 27 | at | Southwestern Texas | 17 | |||
| 10/16/2021 | Howard Payne (7-3,5-3) | 21 | at | Southwestern Texas | 17 | |||
| 10/23/2021 | Southwestern Texas | 7 | at | Hardin-Simmons (9-1,7-1) | 69 | |||
| 10/30/2021 | Austin (1-8) | 19 | at | Southwestern Texas | 45 | SAA | ||
| 11/6/2021 | Southwestern Texas | 24 | at | Texas Lutheran (3-7,2-6) | 14 | |||
| 11/13/2021 | Sul Ross State (2-8,2-6) | 15 | at | Southwestern Texas | 49 |
| vs Southwestern Texas | vs Other Opponents | Southwestern Texas compared to OOs | |
| Record: | 6-4 | 50-41 | |
| Points Scored: | 32.40 | 29.32 | -3.08 |
| Points Allowed: | 23.40 | 26.43 | -3.03 |
| Margin: | 9.00 | 2.89 | -6.11 |
| Total Points: | 55.80 | 55.75 | 0.05 |