| 8/29/2019 | South Dakota State | 21 | at | Minnesota | 28 | MVC (1AA) | ||
| 8/30/2019 | Tulsa | 7 | at | Michigan State | 28 | AAC | ||
| Purdue | 31 | at | Nevada | 34 | @ MW | |||
| Massachusetts | 21 | at | Rutgers | 48 | Ind | |||
| Wisconsin | 49 | at | South Florida | 0 | @ AAC | |||
| 8/31/2019 | Akron | 3 | at | Illinois | 42 | MAC | ||
| Ball State | 24 | vs | Indiana | 34 | Indianapolis IN | vs MAC | ||
| Miami-Ohio | 14 | at | Iowa | 38 | MAC | |||
| Howard | 0 | at | Maryland | 79 | MEAC (1AA) | |||
| Middle Tenn State | 21 | at | Michigan | 40 | CUSA | |||
| South Alabama | 21 | at | Nebraska | 35 | SBC | |||
| Florida Atlantic | 21 | at | Ohio State | 45 | CUSA | |||
| Idaho | 7 | at | Penn State | 79 | BSky (1AA) | |||
| Northwestern | 7 | at | Stanford | 17 | @ P12 | |||
| 9/7/2019 | Nebraska | 31 | at | Colorado | 34 | OT | @ P12 | |
| Illinois | 31 | at | Connecticut | 23 | @ AAC | |||
| Minnesota | 38 | at | Fresno State | 35 | 2OT | @ MW | ||
| Eastern Illinois | 0 | at | Indiana | 52 | OVC (1AA) | |||
| Rutgers | 0 | at | Iowa | 30 | ||||
| Syracuse | 20 | at | Maryland | 63 | ACC | |||
| Army | 21 | at | Michigan | 24 | 2OT | Ind | ||
| Western Michigan | 17 | at | Michigan State | 51 | MAC | |||
| Cincinnati | 0 | at | Ohio State | 42 | AAC | |||
| Buffalo | 13 | at | Penn State | 45 | MAC | |||
| Vanderbilt | 24 | at | Purdue | 42 | SEC | |||
| Central Michigan | 0 | at | Wisconsin | 61 | MAC | |||
| 9/14/2019 | Eastern Michigan | 34 | at | Illinois | 31 | MAC | ||
| Ohio State | 51 | at | Indiana | 10 | ||||
| Iowa | 18 | at | Iowa State | 17 | @ B12 | |||
| Arizona State | 10 | at | Michigan State | 7 | P12 | |||
| Georgia Southern | 32 | at | Minnesota | 35 | SBC | |||
| Northern Illinois | 8 | at | Nebraska | 44 | MAC | |||
| UNLV | 14 | at | Northwestern | 30 | MW | |||
| Pittsburgh | 10 | at | Penn State | 17 | ACC | |||
| TCU | 34 | at | Purdue | 13 | B12 | |||
| Maryland | 17 | at | Temple | 20 | @ AAC | |||
| 9/21/2019 | Nebraska | 42 | at | Illinois | 38 | |||
| Connecticut | 3 | at | Indiana | 38 | AAC | |||
| Michigan State | 31 | at | Northwestern | 10 | ||||
| Miami-Ohio | 5 | at | Ohio State | 76 | MAC | |||
| Boston College | 30 | at | Rutgers | 16 | ACC | |||
| Michigan | 14 | at | Wisconsin | 35 | ||||
| 9/27/2019 | Penn State | 59 | at | Maryland | 0 | |||
| 9/28/2019 | Middle Tenn State | 3 | at | Iowa | 48 | CUSA | ||
| Rutgers | 0 | at | Michigan | 52 | ||||
| Indiana | 31 | at | Michigan State | 40 | ||||
| Ohio State | 48 | at | Nebraska | 7 | ||||
| Minnesota | 38 | at | Purdue | 31 | ||||
| Northwestern | 15 | at | Wisconsin | 24 | ||||
| 10/5/2019 | Iowa | 3 | at | Michigan | 10 | |||
| Illinois | 17 | at | Minnesota | 40 | ||||
| Northwestern | 10 | at | Nebraska | 13 | ||||
| Michigan State | 10 | at | Ohio State | 34 | ||||
| Purdue | 7 | at | Penn State | 35 | ||||
| Maryland | 48 | at | Rutgers | 7 | ||||
| Kent State | 0 | at | Wisconsin | 48 | MAC | |||
| 10/12/2019 | Michigan | 42 | at | Illinois | 25 | |||
| Rutgers | 0 | at | Indiana | 35 | ||||
| Penn State | 17 | at | Iowa | 12 | ||||
| Nebraska | 7 | at | Minnesota | 34 | ||||
| Maryland | 14 | at | Purdue | 40 | ||||
| Michigan State | 0 | at | Wisconsin | 38 | ||||
| 10/18/2019 | Ohio State | 52 | at | Northwestern | 3 | |||
| 10/19/2019 | Wisconsin | 23 | at | Illinois | 24 | |||
| Purdue | 20 | at | Iowa | 26 | ||||
| Indiana | 34 | at | Maryland | 28 | ||||
| Michigan | 21 | at | Penn State | 28 | ||||
| Minnesota | 42 | at | Rutgers | 7 | ||||
| 10/26/2019 | Notre Dame | 14 | at | Michigan | 45 | ND | ||
| Penn State | 28 | at | Michigan State | 7 | ||||
| Maryland | 10 | at | Minnesota | 52 | ||||
| Indiana | 38 | at | Nebraska | 31 | ||||
| Iowa | 20 | at | Northwestern | 0 | ||||
| Wisconsin | 7 | at | Ohio State | 38 | ||||
| Illinois | 24 | at | Purdue | 6 | ||||
| Liberty | 34 | at | Rutgers | 44 | Ind | |||
| 11/2/2019 | Rutgers | 10 | at | Illinois | 38 | |||
| Northwestern | 3 | at | Indiana | 34 | ||||
| Michigan | 38 | at | Maryland | 7 | ||||
| Nebraska | 27 | at | Purdue | 31 | ||||
| 11/9/2019 | Illinois | 37 | at | Michigan State | 34 | |||
| Penn State | 26 | at | Minnesota | 31 | ||||
| Purdue | 24 | at | Northwestern | 22 | ||||
| Maryland | 14 | at | Ohio State | 73 | ||||
| Iowa | 22 | at | Wisconsin | 24 | ||||
| 11/16/2019 | Minnesota | 19 | at | Iowa | 23 | |||
| Michigan State | 10 | at | Michigan | 44 | ||||
| Wisconsin | 37 | at | Nebraska | 21 | ||||
| Massachusetts | 6 | at | Northwestern | 45 | Ind | |||
| Indiana | 27 | at | Penn State | 34 | ||||
| Ohio State | 56 | at | Rutgers | 21 | ||||
| 11/23/2019 | Michigan | 39 | at | Indiana | 14 | |||
| Illinois | 10 | at | Iowa | 19 | ||||
| Nebraska | 54 | at | Maryland | 7 | ||||
| Minnesota | 38 | at | Northwestern | 22 | ||||
| Penn State | 17 | at | Ohio State | 28 | ||||
| Michigan State | 27 | at | Rutgers | 0 | ||||
| Purdue | 24 | at | Wisconsin | 45 | ||||
| 11/29/2019 | Iowa | 27 | at | Nebraska | 24 | |||
| 11/30/2019 | Northwestern | 29 | at | Illinois | 10 | |||
| Ohio State | 56 | at | Michigan | 27 | ||||
| Maryland | 16 | at | Michigan State | 19 | ||||
| Wisconsin | 38 | at | Minnesota | 17 | ||||
| Rutgers | 6 | at | Penn State | 27 | ||||
| Indiana | 44 | at | Purdue | 41 | 2OT | |||
| 12/7/2019 | Wisconsin | 21 | vs | Ohio State | 34 | B1G Championship - Indianapolis IN | ||
| 12/27/2019 | Southern California | 24 | vs | Iowa | 49 | Holiday Bowl - San Diego CA | vs P12 | |
| Michigan State | 27 | vs | Wake Forest | 21 | Pinstripe Bowl - New York NY | vs ACC | ||
| 12/28/2019 | Clemson | 29 | vs | Ohio State | 23 | 1A Semifinal - Fiesta Bowl - Glendale AZ | vs ACC | |
| Memphis | 39 | vs | Penn State | 53 | Cotton Bowl - Arlington TX | vs AAC | ||
| 12/30/2019 | California | 35 | vs | Illinois | 20 | Redbox Bowl - Santa Clara CA | vs P12 | |
| 1/1/2020 | Michigan | 16 | vs | Alabama | 35 | Citrus Bowl - Orlando FL | vs SEC | |
| Minnesota | 31 | vs | Auburn | 24 | Outback Bowl - Tampa FL | vs SEC | ||
| Oregon | 28 | vs | Wisconsin | 27 | Rose Bowl - Pasadena CA | vs P12 | ||
| 1/2/2020 | Indiana | 22 | vs | Tennessee | 23 | Gator Bowl - Jacksonville FL | vs SEC |