| 8/30/2019 | Utah State (7-6) | 35 | at | Wake Forest | 38 | MW | ||
| 9/6/2019 | Wake Forest | 41 | at | Rice (3-9) | 21 | at CUSA | ||
| 9/13/2019 | North Carolina (7-6,4-5) | 18 | at | Wake Forest | 24 | |||
| 9/21/2019 | Elon (5-6) | 7 | at | Wake Forest | 49 | CAAF (1AA) | ||
| 9/28/2019 | Wake Forest | 27 | at | Boston College (6-7,4-4) | 24 | |||
| 10/12/2019 | Louisville (8-5,5-3) | 62 | at | Wake Forest | 59 | |||
| 10/19/2019 | Florida State (6-7,4-4) | 20 | at | Wake Forest | 22 | |||
| 11/2/2019 | North Carolina State (4-8,1-7) | 10 | at | Wake Forest | 44 | |||
| 11/9/2019 | Wake Forest | 17 | at | Virginia Tech (8-5,5-3) | 36 | |||
| 11/16/2019 | Wake Forest | 3 | at | Clemson (14-1,9-0) | 52 | |||
| 11/23/2019 | Duke (5-7,3-5) | 27 | at | Wake Forest | 39 | |||
| 11/30/2019 | Wake Forest | 30 | at | Syracuse (5-7,2-6) | 39 | OT | ||
| 12/27/2019 | Michigan State (7-6) | 27 | vs | Wake Forest | 21 | Pinstripe Bowl - New York NY | B10 |
| vs Wake Forest | vs Other Opponents | Wake Forest compared to OOs | |
| Record: | 5-8 | 80-72 | |
| Points Scored: | 29.08 | 28.63 | -0.45 |
| Points Allowed: | 31.85 | 26.39 | 5.46 |
| Margin: | -2.77 | 2.24 | 5.01 |
| Total Points: | 60.93 | 55.02 | 5.91 |