| 8/31/2019 | Northern Iowa (10-5) | 26 | at | Iowa State | 29 | 3OT | MVC (1AA) | |
| 9/14/2019 | Iowa (10-3) | 18 | at | Iowa State | 17 | B10 | ||
| 9/21/2019 | UL Monroe (5-7) | 20 | at | Iowa State | 72 | SBC | ||
| 9/28/2019 | Iowa State | 21 | at | Baylor (11-3,8-2) | 23 | |||
| 10/5/2019 | TCU (5-7,3-6) | 24 | at | Iowa State | 49 | |||
| 10/12/2019 | Iowa State | 38 | at | West Virginia (5-7,3-6) | 14 | |||
| 10/19/2019 | Iowa State | 34 | at | Texas Tech (4-8,2-7) | 24 | |||
| 10/26/2019 | Oklahoma State (8-5,5-4) | 34 | at | Iowa State | 27 | |||
| 11/9/2019 | Iowa State | 41 | at | Oklahoma (12-2,9-1) | 42 | |||
| 11/16/2019 | Texas (8-5,5-4) | 21 | at | Iowa State | 23 | |||
| 11/23/2019 | Kansas (3-9,1-8) | 31 | at | Iowa State | 41 | |||
| 11/30/2019 | Iowa State | 17 | at | Kansas State (8-5,5-4) | 27 | |||
| 12/28/2019 | Notre Dame (11-2) | 33 | vs | Iowa State | 9 | Camping World Bowl - Orlando FL | ND |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 6-7 | 94-61 | |
| Points Scored: | 25.92 | 30.68 | 4.76 |
| Points Allowed: | 32.15 | 24.70 | 7.45 |
| Margin: | -6.23 | 5.98 | 12.21 |
| Total Points: | 58.07 | 55.38 | 2.69 |