| 8/29/2019 | South Dakota State | 21 | at | Minnesota (11-2) | 28 | at B10 | ||
| 9/7/2019 | LIU (0-10) | 3 | at | South Dakota State | 38 | NE | ||
| 9/14/2019 | Drake (6-5) | 10 | at | South Dakota State | 38 | Pio | ||
| 9/21/2019 | Southern Utah (3-9) | 7 | at | South Dakota State | 43 | BSky | ||
| 10/5/2019 | Southern Illinois (7-5,5-3) | 10 | at | South Dakota State | 28 | |||
| 10/12/2019 | South Dakota State | 38 | at | Youngstown State (6-6,2-6) | 28 | |||
| 10/19/2019 | South Dakota State | 42 | at | Indiana State (5-7,3-5) | 23 | |||
| 10/26/2019 | North Dakota State (16-0,9-0) | 23 | at | South Dakota State | 16 | |||
| 11/2/2019 | South Dakota State | 35 | at | Missouri State (1-10,1-7) | 14 | |||
| 11/9/2019 | Illinois State (10-5,5-4) | 27 | at | South Dakota State | 18 | |||
| 11/16/2019 | Northern Iowa (10-5,7-2) | 7 | at | South Dakota State | 38 | |||
| 11/23/2019 | South Dakota State | 21 | at | South Dakota (5-7,4-4) | 24 | |||
| 12/7/2019 | Northern Iowa (10-5,7-2) | 13 | at | South Dakota State | 10 | 1AA Playoff Round 2 |
| vs South Dakota State | vs Other Opponents | South Dakota State compared to OOs | |
| Record: | 5-8 | 84-67 | |
| Points Scored: | 16.69 | 25.74 | 9.05 |
| Points Allowed: | 29.69 | 23.51 | 6.18 |
| Margin: | -13.00 | 2.23 | 15.23 |
| Total Points: | 46.38 | 49.25 | -2.87 |