| 8/31/2019 | Fresno State (4-8) | 23 | at | Southern California | 31 | MW | ||
| 9/7/2019 | Stanford (4-8,3-6) | 20 | at | Southern California | 45 | |||
| 9/14/2019 | Southern California | 27 | at | BYU (7-6) | 30 | OT | at Ind | |
| 9/20/2019 | Utah (11-3,8-2) | 23 | at | Southern California | 30 | |||
| 9/28/2019 | Southern California | 14 | at | Washington (8-5,4-5) | 28 | |||
| 10/12/2019 | Southern California | 27 | at | Notre Dame (11-2) | 30 | at ND | ||
| 10/19/2019 | Arizona (4-8,2-7) | 14 | at | Southern California | 41 | |||
| 10/25/2019 | Southern California | 35 | at | Colorado (5-7,3-6) | 31 | |||
| 11/2/2019 | Oregon (12-2,9-1) | 56 | at | Southern California | 24 | |||
| 11/9/2019 | Southern California | 31 | at | Arizona State (8-5,4-5) | 26 | |||
| 11/16/2019 | Southern California | 41 | at | California (8-5,4-5) | 17 | |||
| 11/23/2019 | UCLA (4-8,4-5) | 35 | at | Southern California | 52 | |||
| 12/27/2019 | Southern California | 24 | vs | Iowa (10-3) | 49 | Holiday Bowl - San Diego CA | vs B10 |
| vs Southern California | vs Other Opponents | Southern California compared to OOs | |
| Record: | 5-8 | 91-62 | |
| Points Scored: | 29.38 | 28.15 | -1.23 |
| Points Allowed: | 32.46 | 23.14 | 9.32 |
| Margin: | -3.08 | 5.01 | 8.09 |
| Total Points: | 61.84 | 51.29 | 10.55 |