| 8/30/2019 | Wisconsin (10-4) | 49 | at | South Florida | 0 | B10 | ||
| 9/7/2019 | South Florida | 10 | at | Georgia Tech (3-9) | 14 | at ACC | ||
| 9/14/2019 | South Carolina State (8-3) | 16 | at | South Florida | 55 | MEAC (1AA) | ||
| 9/28/2019 | SMU (10-3,6-2) | 48 | at | South Florida | 21 | |||
| 10/5/2019 | South Florida | 48 | at | Connecticut (2-10,0-8) | 22 | |||
| 10/12/2019 | BYU (7-6) | 23 | at | South Florida | 27 | Ind | ||
| 10/19/2019 | South Florida | 3 | at | Navy (11-2,7-1) | 35 | |||
| 10/26/2019 | South Florida | 45 | at | East Carolina (4-8,1-7) | 20 | |||
| 11/7/2019 | Temple (8-5,5-3) | 17 | at | South Florida | 7 | |||
| 11/16/2019 | Cincinnati (11-3,7-2) | 20 | at | South Florida | 17 | |||
| 11/23/2019 | Memphis (12-2,8-1) | 49 | at | South Florida | 10 | |||
| 11/29/2019 | South Florida | 7 | at | UCF (10-3,6-2) | 34 |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 8-4 | 88-54 | |
| Points Scored: | 28.92 | 31.64 | 2.72 |
| Points Allowed: | 20.83 | 27.03 | -6.20 |
| Margin: | 8.09 | 4.61 | -3.48 |
| Total Points: | 49.75 | 58.67 | -8.92 |