| 8/29/2019 | Robert Morris (7-5) | 10 | at | Buffalo | 38 | NE (1AA) | ||
| 9/7/2019 | Buffalo | 13 | at | Penn State (11-2) | 45 | at B10 | ||
| 9/14/2019 | Buffalo | 17 | at | Liberty (8-5) | 35 | at Ind | ||
| 9/21/2019 | Temple (8-5) | 22 | at | Buffalo | 38 | AAC | ||
| 9/28/2019 | Buffalo | 20 | at | Miami-Ohio (8-6,7-2) | 34 | |||
| 10/5/2019 | Ohio (7-6,5-3) | 21 | at | Buffalo | 20 | OT | ||
| 10/19/2019 | Buffalo | 21 | at | Akron (0-12,0-8) | 0 | |||
| 10/26/2019 | Central Michigan (8-6,6-3) | 20 | at | Buffalo | 43 | |||
| 11/2/2019 | Buffalo | 43 | at | Eastern Michigan (6-7,3-5) | 14 | |||
| 11/14/2019 | Buffalo | 27 | at | Kent State (7-6,5-3) | 30 | |||
| 11/20/2019 | Toledo (6-6,3-5) | 30 | at | Buffalo | 49 | |||
| 11/29/2019 | Bowling Green (3-9,2-6) | 7 | at | Buffalo | 49 | |||
| 12/20/2019 | Buffalo | 31 | vs | UNC-Charlotte (7-6) | 9 | Bahamas Bowl | vs CUSA |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 5-8 | 81-73 | |
| Points Scored: | 21.31 | 27.44 | 6.13 |
| Points Allowed: | 31.46 | 28.93 | 2.53 |
| Margin: | -10.15 | -1.49 | 8.66 |
| Total Points: | 52.77 | 56.37 | -3.60 |