| 8/24/2019 | Miami-Florida | 20 | vs | Florida | 24 | Orlando FL | vs SEC | |
| 8/29/2019 | Georgia Tech | 14 | at | Clemson | 52 | |||
| 8/30/2019 | Utah State | 35 | at | Wake Forest | 38 | MW | ||
| 8/31/2019 | Duke | 3 | vs | Alabama | 42 | Atlanta GA | vs SEC | |
| Virginia Tech | 28 | at | Boston College | 35 | ||||
| Boise State | 36 | at | Florida State | 31 | MW | |||
| Syracuse | 24 | at | Liberty | 0 | @ Ind | |||
| East Carolina | 6 | at | North Carolina State | 34 | AAC | |||
| Virginia | 30 | at | Pittsburgh | 14 | ||||
| North Carolina | 24 | vs | South Carolina | 20 | Charlotte NC | vs SEC | ||
| 9/2/2019 | Notre Dame | 35 | at | Louisville | 17 | ND | ||
| 9/6/2019 | Wake Forest | 41 | at | Rice | 21 | @ CUSA | ||
| William & Mary | 17 | at | Virginia | 52 | CAAF (1AA) | |||
| 9/7/2019 | Richmond | 13 | at | Boston College | 45 | CAAF (1AA) | ||
| Texas A&M | 10 | at | Clemson | 24 | SEC | |||
| North Carolina A&T | 13 | at | Duke | 45 | MEAC (1AA) | |||
| UL Monroe | 44 | at | Florida State | 45 | OT | SBC | ||
| South Florida | 10 | at | Georgia Tech | 14 | AAC | |||
| Eastern Kentucky | 0 | at | Louisville | 42 | OVC (1AA) | |||
| Syracuse | 20 | at | Maryland | 63 | @ B10 | |||
| Miami-Florida | 25 | at | North Carolina | 28 | ||||
| Western Carolina | 0 | at | North Carolina State | 41 | SoCon (1AA) | |||
| Ohio | 10 | at | Pittsburgh | 20 | MAC | |||
| Old Dominion | 17 | at | Virginia Tech | 31 | CUSA | |||
| 9/13/2019 | Kansas | 48 | at | Boston College | 24 | B12 | ||
| North Carolina | 18 | at | Wake Forest | 24 | ||||
| 9/14/2019 | The Citadel | 27 | at | Georgia Tech | 24 | OT | SoCon (1AA) | |
| Bethune-Cookman | 0 | at | Miami-Florida | 63 | MEAC (1AA) | |||
| Duke | 41 | at | Middle Tenn State | 18 | @ CUSA | |||
| Pittsburgh | 10 | at | Penn State | 17 | @ B10 | |||
| Clemson | 41 | at | Syracuse | 6 | ||||
| Florida State | 24 | at | Virginia | 31 | ||||
| Furman | 17 | at | Virginia Tech | 24 | SoCon (1AA) | |||
| North Carolina State | 27 | at | West Virginia | 44 | @ B12 | |||
| Louisville | 38 | vs | Western Kentucky | 21 | Nashville TN | vs CUSA | ||
| 9/21/2019 | UNC-Charlotte | 10 | at | Clemson | 52 | CUSA | ||
| Louisville | 24 | at | Florida State | 35 | ||||
| Central Michigan | 12 | at | Miami-Florida | 17 | MAC | |||
| Appalachian State | 34 | at | North Carolina | 31 | SBC | |||
| Ball State | 23 | at | North Carolina State | 34 | MAC | |||
| UCF | 34 | at | Pittsburgh | 35 | AAC | |||
| Boston College | 30 | at | Rutgers | 16 | @ B10 | |||
| Western Michigan | 33 | at | Syracuse | 52 | MAC | |||
| Old Dominion | 17 | at | Virginia | 28 | CUSA | |||
| Elon | 7 | at | Wake Forest | 49 | CAAF (1AA) | |||
| 9/27/2019 | Duke | 45 | at | Virginia Tech | 10 | |||
| 9/28/2019 | Wake Forest | 27 | at | Boston College | 24 | |||
| North Carolina State | 13 | at | Florida State | 31 | ||||
| Clemson | 21 | at | North Carolina | 20 | ||||
| Virginia | 20 | at | Notre Dame | 35 | @ ND | |||
| Delaware | 14 | at | Pittsburgh | 17 | CAAF (1AA) | |||
| Holy Cross | 3 | at | Syracuse | 41 | Pat (1AA) | |||
| Georgia Tech | 2 | at | Temple | 24 | @ AAC | |||
| 10/5/2019 | Pittsburgh | 33 | at | Duke | 30 | |||
| North Carolina | 38 | at | Georgia Tech | 22 | ||||
| Boston College | 39 | at | Louisville | 41 | ||||
| Virginia Tech | 42 | at | Miami-Florida | 35 | ||||
| 10/10/2019 | Syracuse | 10 | at | North Carolina State | 16 | |||
| 10/11/2019 | Virginia | 9 | at | Miami-Florida | 17 | |||
| 10/12/2019 | Florida State | 14 | at | Clemson | 45 | |||
| Georgia Tech | 23 | at | Duke | 41 | ||||
| Rhode Island | 17 | at | Virginia Tech | 34 | CAAF (1AA) | |||
| Louisville | 62 | at | Wake Forest | 59 | ||||
| 10/18/2019 | Pittsburgh | 27 | at | Syracuse | 20 | |||
| 10/19/2019 | North Carolina State | 24 | at | Boston College | 45 | |||
| Clemson | 45 | at | Louisville | 10 | ||||
| Georgia Tech | 28 | at | Miami-Florida | 21 | OT | |||
| Duke | 14 | at | Virginia | 48 | ||||
| North Carolina | 41 | at | Virginia Tech | 43 | 6OT | |||
| Florida State | 20 | at | Wake Forest | 22 | ||||
| 10/26/2019 | Boston College | 7 | at | Clemson | 59 | |||
| Syracuse | 17 | at | Florida State | 35 | ||||
| Virginia | 21 | at | Louisville | 28 | ||||
| Duke | 17 | at | North Carolina | 20 | ||||
| Miami-Florida | 16 | at | Pittsburgh | 12 | ||||
| 11/2/2019 | Wofford | 14 | at | Clemson | 59 | SoCon (1AA) | ||
| Miami-Florida | 27 | at | Florida State | 10 | ||||
| Pittsburgh | 20 | at | Georgia Tech | 10 | ||||
| Virginia | 38 | at | North Carolina | 31 | ||||
| Virginia Tech | 20 | at | Notre Dame | 21 | @ ND | |||
| Boston College | 58 | at | Syracuse | 27 | ||||
| North Carolina State | 10 | at | Wake Forest | 44 | ||||
| 11/9/2019 | Florida State | 38 | at | Boston College | 31 | |||
| Notre Dame | 38 | at | Duke | 7 | ND | |||
| Louisville | 27 | at | Miami-Florida | 52 | ||||
| Clemson | 55 | at | North Carolina State | 10 | ||||
| Georgia Tech | 28 | at | Virginia | 33 | ||||
| Wake Forest | 17 | at | Virginia Tech | 36 | ||||
| 11/14/2019 | North Carolina | 27 | at | Pittsburgh | 34 | |||
| 11/16/2019 | Wake Forest | 3 | at | Clemson | 52 | |||
| Syracuse | 49 | at | Duke | 6 | ||||
| Alabama State | 12 | at | Florida State | 49 | SWAC (1AA) | |||
| Virginia Tech | 45 | at | Georgia Tech | 0 | ||||
| Louisville | 34 | at | North Carolina State | 20 | ||||
| 11/21/2019 | North Carolina State | 26 | at | Georgia Tech | 28 | |||
| 11/23/2019 | Miami-Florida | 24 | at | Florida Intl | 30 | @ CUSA | ||
| Syracuse | 34 | at | Louisville | 56 | ||||
| Mercer | 7 | at | North Carolina | 56 | SoCon (1AA) | |||
| Boston College | 7 | at | Notre Dame | 40 | @ ND | |||
| Liberty | 27 | at | Virginia | 55 | Ind | |||
| Pittsburgh | 0 | at | Virginia Tech | 28 | ||||
| Duke | 27 | at | Wake Forest | 39 | ||||
| 11/29/2019 | Virginia Tech | 30 | at | Virginia | 39 | |||
| 11/30/2019 | Miami-Florida | 17 | at | Duke | 27 | |||
| Florida State | 17 | at | Florida | 40 | @ SEC | |||
| Georgia | 52 | at | Georgia Tech | 7 | SEC | |||
| Louisville | 13 | at | Kentucky | 45 | @ SEC | |||
| North Carolina | 41 | at | North Carolina State | 10 | ||||
| Boston College | 26 | at | Pittsburgh | 19 | ||||
| Clemson | 38 | at | South Carolina | 3 | @ SEC | |||
| Wake Forest | 30 | at | Syracuse | 39 | OT | |||
| 12/7/2019 | Virginia | 17 | vs | Clemson | 62 | ACC Championship - Charlotte NC | ||
| 12/26/2019 | Pittsburgh | 34 | vs | Eastern Michigan | 30 | Quick Lane Bowl - Detroiut MI | vs MAC | |
| Louisiana Tech | 14 | vs | Miami-Florida | 0 | Independence Bowl - Shreveport LA | vs CUSA | ||
| 12/27/2019 | North Carolina | 55 | vs | Temple | 13 | Military Bowl - Annapolis MD | vs AAC | |
| Michigan State | 27 | vs | Wake Forest | 21 | Pinstripe Bowl - New York NY | vs B10 | ||
| 12/28/2019 | Clemson | 29 | vs | Ohio State | 23 | 1A Semifinal - Fiesta Bowl - Glendale AZ | vs B10 | |
| 12/30/2019 | Mississippi State | 28 | vs | Louisville | 38 | Music City Bowl - Nashville TN | vs SEC | |
| Florida | 36 | vs | Virginia | 28 | Orange Bowl - Miami Gardens FL | vs SEC | ||
| 12/31/2019 | Florida State | 14 | vs | Arizona State | 20 | Sun Bowl - El Paso TX | vs P12 | |
| Virginia Tech | 30 | vs | Kentucky | 37 | Belk Bowl - Charlotte NC | vs SEC | ||
| 1/2/2020 | Boston College | 6 | vs | Cincinnati | 38 | Birmingham Bowl - Birmingham AL | vs AAC | |
| 1/13/2020 | Clemson | 25 | vs | LSU | 42 | 1A Championsip - New Orleans LA | vs SEC |