| 8/29/2019 | Valparaiso (1-11) | 7 | at | Eastern Kentucky | 53 | Pio | ||
| 9/7/2019 | Eastern Kentucky | 0 | at | Louisville (8-5) | 42 | at ACC | ||
| 9/14/2019 | Eastern Kentucky | 7 | at | Indiana State (5-7) | 19 | at MVC | ||
| 9/21/2019 | Eastern Kentucky | 35 | at | Presbyterian (2-10) | 10 | at BigS | ||
| 9/28/2019 | Tennessee State (3-9,2-6) | 16 | at | Eastern Kentucky | 42 | |||
| 10/5/2019 | Tennessee-Martin (7-5,6-2) | 38 | at | Eastern Kentucky | 28 | |||
| 10/19/2019 | Eastern Kentucky | 34 | at | Murray State (4-8,2-6) | 27 | |||
| 10/26/2019 | Eastern Kentucky | 33 | at | Eastern Illinois (1-11,1-7) | 6 | |||
| 11/2/2019 | Austin Peay (11-4,7-1) | 28 | at | Eastern Kentucky | 21 | OT | ||
| 11/9/2019 | Eastern Kentucky | 31 | at | SE Missouri State (9-4,7-1) | 38 | |||
| 11/16/2019 | Tennessee Tech (6-6,3-5) | 10 | at | Eastern Kentucky | 22 | |||
| 11/23/2019 | Eastern Kentucky | 29 | at | Jacksonville State (6-6,3-5) | 23 |
| vs Eastern Kentucky | vs Other Opponents | Eastern Kentucky compared to OOs | |
| Record: | 5-7 | 58-79 | |
| Points Scored: | 22.00 | 24.93 | 2.93 |
| Points Allowed: | 27.92 | 28.95 | -1.03 |
| Margin: | -5.92 | -4.02 | 1.90 |
| Total Points: | 49.92 | 53.88 | -3.96 |