| 8/31/2019 | East Carolina | 6 | at | North Carolina State (4-8) | 34 | at ACC | ||
| 9/7/2019 | Gardner-Webb (3-9) | 9 | at | East Carolina | 48 | BigS (1AA) | ||
| 9/14/2019 | East Carolina | 10 | at | Navy (11-2,7-1) | 42 | |||
| 9/21/2019 | William & Mary (5-7) | 7 | at | East Carolina | 19 | CAAF (1AA) | ||
| 9/28/2019 | East Carolina | 24 | at | Old Dominion (1-11) | 21 | at CUSA | ||
| 10/3/2019 | Temple (8-5,5-3) | 27 | at | East Carolina | 17 | |||
| 10/19/2019 | East Carolina | 28 | at | UCF (10-3,6-2) | 41 | |||
| 10/26/2019 | South Florida (4-8,2-6) | 45 | at | East Carolina | 20 | |||
| 11/2/2019 | Cincinnati (11-3,7-2) | 46 | at | East Carolina | 43 | |||
| 11/9/2019 | East Carolina | 51 | at | SMU (10-3,6-2) | 59 | |||
| 11/23/2019 | East Carolina | 31 | at | Connecticut (2-10,0-8) | 24 | |||
| 11/30/2019 | Tulsa (4-8,2-6) | 49 | at | East Carolina | 24 |
| vs East Carolina | vs Other Opponents | East Carolina compared to OOs | |
| Record: | 8-4 | 65-73 | |
| Points Scored: | 33.67 | 27.45 | -6.22 |
| Points Allowed: | 26.75 | 29.18 | -2.43 |
| Margin: | 6.92 | -1.73 | -8.65 |
| Total Points: | 60.42 | 56.63 | 3.79 |