| 8/30/2019 | Tulsa (4-8) | 7 | at | Michigan State | 28 | AAC | ||
| 9/7/2019 | Western Michigan (7-6) | 17 | at | Michigan State | 51 | MAC | ||
| 9/14/2019 | Arizona State (8-5) | 10 | at | Michigan State | 7 | P12 | ||
| 9/21/2019 | Michigan State | 31 | at | Northwestern (3-9,1-8) | 10 | |||
| 9/28/2019 | Indiana (8-5,5-4) | 31 | at | Michigan State | 40 | |||
| 10/5/2019 | Michigan State | 10 | at | Ohio State (13-1,10-0) | 34 | |||
| 10/12/2019 | Michigan State | 0 | at | Wisconsin (10-4,7-3) | 38 | |||
| 10/26/2019 | Penn State (11-2,7-2) | 28 | at | Michigan State | 7 | |||
| 11/9/2019 | Illinois (6-7,4-5) | 37 | at | Michigan State | 34 | |||
| 11/16/2019 | Michigan State | 10 | at | Michigan (9-4,6-3) | 44 | |||
| 11/23/2019 | Michigan State | 27 | at | Rutgers (2-10,0-9) | 0 | |||
| 11/30/2019 | Maryland (3-9,1-8) | 16 | at | Michigan State | 19 | |||
| 12/27/2019 | Michigan State | 27 | vs | Wake Forest (8-5) | 21 | Pinstripe Bowl - New York NY | vs ACC |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 6-7 | 86-68 | |
| Points Scored: | 22.54 | 29.99 | 7.45 |
| Points Allowed: | 22.38 | 24.63 | -2.25 |
| Margin: | 0.16 | 5.36 | 5.20 |
| Total Points: | 44.92 | 54.62 | -9.70 |