| 8/30/2018 | Missouri State | 17 | at | Oklahoma State | 58 | MVC (1AA) | ||
| 9/1/2018 | Abilene Christian | 27 | at | Baylor | 55 | SLC (1AA) | ||
| South Dakota State | at | Iowa State | CCD | MVC (1AA) | ||||
| Nicholls State | 26 | at | Kansas | 23 | SLC (1AA) | |||
| South Dakota | 24 | at | Kansas State | 27 | MVC (1AA) | |||
| Texas | 29 | vs | Maryland | 34 | Landover MD | vs B10 | ||
| Florida Atlantic | 14 | at | Oklahoma | 63 | CUSA | |||
| Southern | 7 | at | TCU | 55 | SWAC (1AA) | |||
| West Virginia | 40 | vs | Tennessee | 14 | Charlotte NC | vs SEC | ||
| Mississippi | 47 | vs | Texas Tech | 27 | Houston TX | vs SEC | ||
| 9/7/2018 | TCU | 42 | at | SMU | 12 | @ AAC | ||
| 9/8/2018 | Kansas | 31 | at | Central Michigan | 7 | @ MAC | ||
| Iowa State | 3 | at | Iowa | 13 | @ B10 | |||
| Mississippi State | 31 | at | Kansas State | 10 | SEC | |||
| UCLA | 21 | at | Oklahoma | 49 | P12 | |||
| South Alabama | 13 | at | Oklahoma State | 55 | SBC | |||
| Tulsa | 21 | at | Texas | 28 | AAC | |||
| Lamar | 0 | at | Texas Tech | 77 | SLC (1AA) | |||
| Baylor | 37 | at | Texas-San Antonio | 20 | @ CUSA | |||
| Youngstown State | 17 | at | West Virginia | 52 | MVC (1AA) | |||
| 9/15/2018 | Duke | 40 | at | Baylor | 27 | ACC | ||
| Oklahoma | 37 | at | Iowa State | 27 | ||||
| Rutgers | 14 | at | Kansas | 55 | B10 | |||
| Texas-San Antonio | 17 | at | Kansas State | 41 | CUSA | |||
| West Virginia | vs | North Carolina State | CCD | vs ACC | ||||
| Boise State | 21 | at | Oklahoma State | 44 | MW | |||
| Ohio State | 40 | vs | TCU | 28 | Arlington TX | vs B10 | ||
| Southern California | 14 | at | Texas | 37 | P12 | |||
| Houston | 49 | at | Texas Tech | 63 | AAC | |||
| 9/22/2018 | Kansas | 7 | at | Baylor | 26 | |||
| Akron | 13 | at | Iowa State | 26 | MAC | |||
| Army | 21 | at | Oklahoma | 28 | OT | Ind | ||
| Texas Tech | 41 | at | Oklahoma State | 17 | ||||
| TCU | 16 | at | Texas | 31 | ||||
| Kansas State | 6 | at | West Virginia | 35 | ||||
| 9/29/2018 | Oklahoma State | 48 | at | Kansas | 28 | |||
| Texas | 19 | at | Kansas State | 14 | ||||
| Baylor | 33 | at | Oklahoma | 66 | ||||
| Iowa State | 14 | at | TCU | 17 | ||||
| West Virginia | 42 | at | Texas Tech | 34 | ||||
| 10/6/2018 | Kansas State | 34 | at | Baylor | 37 | |||
| Texas | 48 | vs | Oklahoma | 45 | Dallas TX | |||
| Iowa State | 48 | at | Oklahoma State | 42 | ||||
| Kansas | 22 | at | West Virginia | 38 | ||||
| 10/11/2018 | Texas Tech | 17 | at | TCU | 14 | |||
| 10/13/2018 | West Virginia | 14 | at | Iowa State | 30 | |||
| Oklahoma State | 12 | at | Kansas State | 31 | ||||
| Baylor | 17 | at | Texas | 23 | ||||
| 10/20/2018 | Oklahoma | 52 | at | TCU | 27 | |||
| Kansas | 16 | at | Texas Tech | 48 | ||||
| 10/25/2018 | Baylor | 14 | at | West Virginia | 58 | |||
| 10/27/2018 | Texas Tech | 31 | at | Iowa State | 40 | |||
| TCU | 26 | at | Kansas | 27 | ||||
| Kansas State | 14 | at | Oklahoma | 51 | ||||
| Texas | 35 | at | Oklahoma State | 38 | ||||
| 11/3/2018 | Oklahoma State | 31 | at | Baylor | 35 | |||
| Iowa State | 27 | at | Kansas | 3 | ||||
| Kansas State | 13 | at | TCU | 14 | ||||
| West Virginia | 42 | at | Texas | 41 | ||||
| Oklahoma | 51 | at | Texas Tech | 46 | ||||
| 11/10/2018 | Baylor | 14 | at | Iowa State | 28 | |||
| Kansas | 17 | at | Kansas State | 21 | ||||
| Oklahoma State | 47 | at | Oklahoma | 48 | ||||
| Texas | 41 | at | Texas Tech | 34 | ||||
| TCU | 10 | at | West Virginia | 47 | ||||
| 11/17/2018 | TCU | 16 | at | Baylor | 9 | |||
| Texas Tech | 6 | at | Kansas State | 21 | ||||
| Kansas | 40 | at | Oklahoma | 55 | ||||
| West Virginia | 41 | at | Oklahoma State | 45 | ||||
| Iowa State | 10 | at | Texas | 24 | ||||
| 11/23/2018 | Texas | 24 | at | Kansas | 17 | |||
| Oklahoma | 59 | at | West Virginia | 56 | ||||
| 11/24/2018 | Kansas State | 38 | at | Iowa State | 42 | |||
| Oklahoma State | 24 | at | TCU | 31 | ||||
| Baylor | 35 | vs | Texas Tech | 24 | Arlington TX | |||
| 12/1/2018 | Drake | 24 | at | Iowa State | 27 | Pio (1AA) | ||
| Texas | 27 | vs | Oklahoma | 39 | Big 12 Championship Arlington TX | |||
| 12/26/2018 | California | 7 | vs | TCU | 10 | OT | CHEEZ-IT BOWL - Phoenix AZ | vs P12 |
| 12/27/2018 | Baylor | 45 | vs | Vanderbilt | 38 | ACADEMY SPORTS + OUTDOORS TEXAS BOWL - Houston TX | vs SEC | |
| 12/28/2018 | West Virginia | 18 | vs | Syracuse | 34 | CAMPING WORLD BOWL - Orlando FL | vs ACC | |
| Iowa State | 26 | vs | Washington State | 28 | VALERO ALAMO BOWL - San Antonio TX | vs P12 | ||
| 12/29/2018 | Oklahoma | 34 | vs | Alabama | 45 | 1A Semifinal Miami Gardens FL | vs SEC | |
| 12/31/2018 | Missouri | 33 | vs | Oklahoma State | 38 | AUTOZONE LIBERTY BOWL - Memphis | vs SEC | |
| 1/1/2019 | Texas | 28 | vs | Georgia | 21 | ALLSTATE SUGAR BOWL - New Orleans LA | vs SEC |