| 9/1/2018 | Stephen F. Austin (2-8) | 6 | at | Mississippi State | 63 | SLC (1AA) | ||
| 9/8/2018 | Mississippi State | 31 | at | Kansas State (5-7) | 10 | at B12 | ||
| 9/15/2018 | UL Lafayette (7-7) | 10 | at | Mississippi State | 56 | SBC | ||
| 9/22/2018 | Mississippi State | 7 | at | Kentucky (10-3,5-3) | 28 | |||
| 9/29/2018 | Florida (10-3,5-3) | 13 | at | Mississippi State | 6 | |||
| 10/6/2018 | Auburn (8-5,3-5) | 9 | at | Mississippi State | 23 | |||
| 10/20/2018 | Mississippi State | 3 | at | LSU (10-3,5-3) | 19 | |||
| 10/27/2018 | Texas A&M (9-4,5-3) | 13 | at | Mississippi State | 28 | |||
| 11/3/2018 | Louisiana Tech (8-5) | 3 | at | Mississippi State | 45 | CUSA | ||
| 11/10/2018 | Mississippi State | 0 | at | Alabama (14-1,9-0) | 24 | |||
| 11/17/2018 | Arkansas (2-10,0-8) | 6 | at | Mississippi State | 52 | |||
| 11/22/2018 | Mississippi State | 35 | at | Mississippi (5-7,1-7) | 3 | |||
| 1/1/2019 | Mississippi State | 22 | vs | Iowa (9-4) | 27 | OUTBACK BOWL - Tampa FL | vs B10 |
| vs Mississippi State | vs Other Opponents | Mississippi State compared to OOs | |
| Record: | 5-8 | 94-59 | |
| Points Scored: | 13.15 | 32.07 | 18.92 |
| Points Allowed: | 28.54 | 24.43 | 4.11 |
| Margin: | -15.39 | 7.64 | 23.03 |
| Total Points: | 41.69 | 56.50 | -14.81 |