| 9/1/2018 | Northern Illinois (8-6) | 7 | at | Iowa | 33 | MAC | ||
| 9/8/2018 | Iowa State (8-5) | 3 | at | Iowa | 13 | B12 | ||
| 9/15/2018 | Northern Iowa (7-6) | 14 | at | Iowa | 38 | MVC (1AA) | ||
| 9/22/2018 | Wisconsin (8-5,5-4) | 28 | at | Iowa | 17 | |||
| 10/6/2018 | Iowa | 48 | at | Minnesota (7-6,3-6) | 31 | |||
| 10/13/2018 | Iowa | 42 | at | Indiana (5-7,2-7) | 16 | |||
| 10/20/2018 | Maryland (5-7,3-6) | 0 | at | Iowa | 23 | |||
| 10/27/2018 | Iowa | 24 | at | Penn State (9-4,6-3) | 30 | |||
| 11/3/2018 | Iowa | 36 | at | Purdue (6-7,5-4) | 38 | |||
| 11/10/2018 | Northwestern (9-5,8-2) | 14 | at | Iowa | 10 | |||
| 11/17/2018 | Iowa | 63 | at | Illinois (4-8,2-7) | 0 | |||
| 11/23/2018 | Nebraska (4-8,3-6) | 28 | at | Iowa | 31 | |||
| 1/1/2019 | Mississippi State (8-5) | 22 | vs | Iowa | 27 | OUTBACK BOWL - Tampa FL | SEC |
| vs Iowa | vs Other Opponents | Iowa compared to OOs | |
| Record: | 4-9 | 84-70 | |
| Points Scored: | 17.77 | 28.38 | 10.61 |
| Points Allowed: | 31.15 | 24.94 | 6.21 |
| Margin: | -13.38 | 3.44 | 16.82 |
| Total Points: | 48.92 | 53.32 | -4.40 |