| 9/1/2018 | William Jewell (1-9) | at | Drake | CCD | GLV (D2) | |||
| 9/8/2018 | Drake | 16 | at | Montana (6-5) | 48 | at BSky | ||
| 9/15/2018 | Missouri S&T (10-2) | 12 | at | Drake | 52 | GLV (D2) | ||
| 9/29/2018 | Drake | 41 | at | Jacksonville (2-8,1-7) | 9 | |||
| 10/6/2018 | Butler (4-7,2-6) | 6 | at | Drake | 36 | |||
| 10/13/2018 | Stetson (8-2,6-2) | 23 | at | Drake | 21 | |||
| 10/20/2018 | Drake | 28 | at | Dayton (6-5,5-3) | 17 | |||
| 10/27/2018 | Drake | 42 | at | Valparaiso (2-9,2-6) | 25 | |||
| 11/3/2018 | San Diego (9-3,8-0) | 27 | at | Drake | 10 | |||
| 11/10/2018 | Marist (5-6,5-3) | 10 | at | Drake | 13 | |||
| 11/17/2018 | Drake | 43 | at | Morehead State (3-8,2-6) | 6 | |||
| 12/1/2018 | Drake | 24 | at | Iowa State (8-5) | 27 | at B12 |
| vs Drake | vs Other Opponents | Drake compared to OOs | |
| Record: | 4-7 | 60-62 | |
| Points Scored: | 19.09 | 30.57 | 11.48 |
| Points Allowed: | 29.64 | 30.70 | -1.06 |
| Margin: | -10.55 | -0.13 | 10.42 |
| Total Points: | 48.73 | 61.27 | -12.54 |