| 9/1/2018 | Louisiana Tech (8-5) | 30 | at | South Alabama | 26 | CUSA | ||
| 9/8/2018 | South Alabama | 13 | at | Oklahoma State (7-6) | 55 | at B12 | ||
| 9/15/2018 | Texas State (3-9,1-7) | 31 | at | South Alabama | 41 | |||
| 9/22/2018 | South Alabama | 35 | at | Memphis (8-6) | 52 | at AAC | ||
| 9/29/2018 | South Alabama | 7 | at | Appalachian State (11-2,8-1) | 52 | |||
| 10/6/2018 | South Alabama | 13 | at | Georgia Southern (10-3,6-2) | 48 | |||
| 10/13/2018 | Alabama State (4-7) | 7 | at | South Alabama | 45 | SWAC (1AA) | ||
| 10/23/2018 | Troy (10-3,7-1) | 38 | at | South Alabama | 17 | |||
| 11/3/2018 | South Alabama | 14 | at | Arkansas State (8-5,5-3) | 38 | |||
| 11/10/2018 | UL Monroe (6-6,4-4) | 38 | at | South Alabama | 10 | |||
| 11/17/2018 | South Alabama | 38 | at | UL Lafayette (7-7,5-4) | 48 | |||
| 11/23/2018 | Coastal Carolina (5-7,2-6) | 28 | at | South Alabama | 31 |
| vs South Alabama | vs Other Opponents | South Alabama compared to OOs | |
| Record: | 9-3 | 78-63 | |
| Points Scored: | 38.75 | 29.23 | -9.52 |
| Points Allowed: | 24.17 | 28.19 | -4.02 |
| Margin: | 14.58 | 1.04 | -13.54 |
| Total Points: | 62.92 | 57.42 | 5.50 |