| 9/1/2018 | Nicholls State | 26 | at | Kansas (3-9) | 23 | at B12 | ||
| 9/8/2018 | Nicholls State | 17 | at | Tulane (7-6) | 42 | at AAC | ||
| 9/15/2018 | Nicholls State | 10 | at | McNeese State (6-5,5-4) | 20 | |||
| 9/22/2018 | Sam Houston (6-5,5-4) | 7 | at | Nicholls State | 27 | |||
| 9/29/2018 | Lamar (7-5,6-3) | 27 | at | Nicholls State | 50 | |||
| 10/6/2018 | Nicholls State | 28 | at | Northwestern State (5-6,4-5) | 10 | |||
| 10/13/2018 | Nicholls State | 12 | at | Abilene Christian (6-5,5-4) | 28 | |||
| 10/27/2018 | Incarnate Word (6-5,6-2) | 21 | at | Nicholls State | 48 | |||
| 11/3/2018 | Nicholls State | 41 | at | Houston Baptist (1-10,0-9) | 20 | |||
| 11/10/2018 | Stephen F. Austin (2-8,2-7) | 14 | at | Nicholls State | 47 | |||
| 11/15/2018 | Southeastern Louisiana (4-7,4-5) | 0 | at | Nicholls State | 44 | |||
| 11/24/2018 | San Diego (9-3) | 30 | at | Nicholls State | 49 | Pio | ||
| 12/1/2018 | Nicholls State | 21 | at | Eastern Washington (12-3) | 42 | 1AA Playoff Round 2 | at BSky |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 4-9 | 70-68 | |
| Points Scored: | 21.85 | 30.04 | 8.19 |
| Points Allowed: | 32.31 | 29.98 | 2.33 |
| Margin: | -10.46 | 0.06 | 10.52 |
| Total Points: | 54.16 | 60.02 | -5.86 |