| 9/1/2018 | Southern | 7 | at | TCU (7-6) | 55 | at B12 | ||
| 9/8/2018 | Southern | 17 | at | Louisiana Tech (8-5) | 54 | at CUSA | ||
| 9/15/2018 | Langston (8-2) | 18 | at | Southern | 33 | Soon (NAIA) | ||
| 9/22/2018 | Southern | 29 | vs | Alabama A&M (6-5,5-3) | 27 | Mobile AL | ||
| 9/29/2018 | Alcorn State (9-4,8-1) | 20 | at | Southern | 3 | |||
| 10/13/2018 | Southern | 38 | at | Prairie View (5-6,4-3) | 0 | |||
| 10/20/2018 | Texas Southern (2-9,1-7) | 7 | vs | Southern | 21 | Dallas TX | ||
| 10/27/2018 | Jackson State (5-5,4-3) | 7 | at | Southern | 41 | |||
| 11/10/2018 | Ark Pine Bluff (2-9,1-6) | 24 | at | Southern | 56 | |||
| 11/24/2018 | Grambling (6-5,5-3) | 28 | vs | Southern | 38 | New Orleans LA | ||
| 12/1/2018 | Southern | 28 | vs | Alcorn State (9-4,8-1) | 37 | SWAC championship |
| vs Southern | vs Other Opponents | Southern compared to OOs | |
| Record: | 4-7 | 61-53 | |
| Points Scored: | 25.18 | 28.57 | 3.39 |
| Points Allowed: | 28.27 | 26.59 | 1.68 |
| Margin: | -3.09 | 1.98 | 5.07 |
| Total Points: | 53.45 | 55.16 | -1.71 |