| 9/1/2018 | Houston | 45 | at | Rice (2-11) | 27 | at CUSA | ||
| 9/8/2018 | Arizona (5-7) | 18 | at | Houston | 45 | P12 | ||
| 9/15/2018 | Houston | 49 | at | Texas Tech (5-7) | 63 | at B12 | ||
| 9/22/2018 | Texas Southern (2-9) | 14 | at | Houston | 70 | SWAC (1AA) | ||
| 10/4/2018 | Tulsa (3-9,2-6) | 26 | at | Houston | 41 | |||
| 10/13/2018 | Houston | 42 | at | East Carolina (3-9,1-7) | 20 | |||
| 10/20/2018 | Houston | 49 | at | Navy (3-10,2-6) | 36 | |||
| 10/27/2018 | South Florida (7-6,3-5) | 36 | at | Houston | 57 | |||
| 11/3/2018 | Houston | 31 | at | SMU (5-7,4-4) | 45 | |||
| 11/10/2018 | Temple (8-5,7-1) | 59 | at | Houston | 49 | |||
| 11/15/2018 | Tulane (7-6,5-3) | 17 | at | Houston | 48 | |||
| 11/23/2018 | Houston | 31 | at | Memphis (8-6,5-4) | 52 | |||
| 12/22/2018 | Houston | 14 | vs | Army (11-2) | 70 | LOCKHEED MARTIN ARMED FORCES BOWL - Fort Worth TX | vs Ind |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 5-8 | 64-86 | |
| Points Scored: | 37.15 | 28.33 | -8.82 |
| Points Allowed: | 43.92 | 29.94 | 13.98 |
| Margin: | -6.77 | -1.61 | 5.16 |
| Total Points: | 81.07 | 58.27 | 22.80 |