| 8/31/2017 | Rhode Island | 27 | at | Central Michigan | 30 | 3OT | CAAF (1AA) | |
| Buffalo | 7 | at | Minnesota | 17 | @ B10 | |||
| Elon | 13 | at | Toledo | 47 | CAAF (1AA) | |||
| 9/1/2017 | UNC-Charlotte | 7 | at | Eastern Michigan | 24 | CUSA | ||
| Boston College | 23 | at | Northern Illinois | 20 | ACC | |||
| 9/2/2017 | Kent State | 3 | at | Clemson | 56 | @ ACC | ||
| Ball State | 21 | at | Illinois | 24 | @ B10 | |||
| Miami-Ohio | 26 | at | Marshall | 31 | @ CUSA | |||
| Bowling Green | 10 | at | Michigan State | 35 | @ B10 | |||
| Hampton | 0 | at | Ohio | 59 | MEAC (1AA) | |||
| Akron | 0 | at | Penn State | 52 | @ B10 | |||
| Western Michigan | 31 | at | Southern California | 49 | @ P12 | |||
| 9/8/2017 | Ohio | 21 | at | Purdue | 44 | @ B10 | ||
| 9/9/2017 | Ark Pine Bluff | 3 | at | Akron | 52 | SWAC (1AA) | ||
| Buffalo | 17 | at | Army | 21 | @ Ind | |||
| UAB | 31 | at | Ball State | 51 | CUSA | |||
| South Dakota | 35 | at | Bowling Green | 27 | MVC (1AA) | |||
| Central Michigan | 45 | at | Kansas | 27 | @ B12 | |||
| Howard | 31 | at | Kent State | 38 | MEAC (1AA) | |||
| Austin Peay | 10 | at | Miami-Ohio | 31 | OVC (1AA) | |||
| Western Michigan | 14 | at | Michigan State | 28 | @ B10 | |||
| Toledo | 37 | at | Nevada | 24 | @ MW | |||
| Eastern Illinois | 10 | at | Northern Illinois | 38 | OVC (1AA) | |||
| Eastern Michigan | 16 | at | Rutgers | 13 | @ B10 | |||
| 9/16/2017 | Iowa State | 41 | at | Akron | 14 | B12 | ||
| Tennessee Tech | 13 | at | Ball State | 28 | OVC (1AA) | |||
| Colgate | 10 | at | Buffalo | 33 | Pat (1AA) | |||
| Kent State | 0 | at | Marshall | 21 | @ CUSA | |||
| Cincinnati | 21 | at | Miami-Ohio | 17 | AAC | |||
| Northern Illinois | 21 | at | Nebraska | 17 | @ B10 | |||
| Bowling Green | 7 | at | Northwestern | 49 | @ B10 | |||
| Kansas | 30 | at | Ohio | 42 | B12 | |||
| Central Michigan | 17 | at | Syracuse | 41 | @ ACC | |||
| Tulsa | 51 | at | Toledo | 54 | AAC | |||
| Idaho | 28 | at | Western Michigan | 37 | SBC | |||
| 9/23/2017 | Florida Atlantic | 31 | at | Buffalo | 34 | CUSA | ||
| Miami-Ohio | 31 | at | Central Michigan | 14 | ||||
| Ohio | 27 | at | Eastern Michigan | 20 | 2OT | |||
| Kent State | 3 | at | Louisville | 42 | @ ACC | |||
| Toledo | 30 | at | Miami-Florida | 52 | @ ACC | |||
| Bowling Green | 13 | at | Middle Tenn State | 24 | @ CUSA | |||
| Akron | 17 | at | Troy | 22 | @ SBC | |||
| Ball State | 21 | at | Western Kentucky | 33 | @ CUSA | |||
| Wagner | 14 | at | Western Michigan | 49 | NE (1AA) | |||
| 9/30/2017 | Central Michigan | 8 | at | Boston College | 28 | @ ACC | ||
| Akron | 34 | at | Bowling Green | 23 | ||||
| Buffalo | 27 | at | Kent State | 13 | ||||
| Eastern Michigan | 20 | at | Kentucky | 24 | @ SEC | |||
| Ohio | 58 | at | Massachusetts | 50 | @ Ind | |||
| Miami-Ohio | 17 | at | Notre Dame | 52 | @ ND | |||
| Northern Illinois | 28 | at | San Diego State | 34 | @ MW | |||
| Ball State | 3 | at | Western Michigan | 55 | ||||
| 10/7/2017 | Ball State | 3 | at | Akron | 31 | |||
| Western Michigan | 71 | at | Buffalo | 68 | 7OT | |||
| Bowling Green | 37 | at | Miami-Ohio | 29 | ||||
| Kent State | 3 | at | Northern Illinois | 24 | ||||
| Central Michigan | 26 | at | Ohio | 23 | ||||
| Eastern Michigan | 15 | at | Toledo | 20 | ||||
| 10/14/2017 | Eastern Michigan | 27 | at | Army | 28 | @ Ind | ||
| Ohio | 48 | at | Bowling Green | 30 | ||||
| Northern Illinois | 14 | at | Buffalo | 13 | ||||
| Toledo | 30 | at | Central Michigan | 10 | ||||
| Miami-Ohio | 14 | at | Kent State | 17 | ||||
| Akron | at | Western Michigan | Postponed | |||||
| 10/15/2017 | Akron | 14 | at | Western Michigan | 13 | |||
| 10/21/2017 | Central Michigan | 56 | at | Ball State | 9 | |||
| Northern Illinois | 48 | at | Bowling Green | 17 | ||||
| Western Michigan | 20 | at | Eastern Michigan | 17 | OT | |||
| Buffalo | 14 | at | Miami-Ohio | 24 | ||||
| Kent State | 3 | at | Ohio | 48 | ||||
| Akron | 21 | at | Toledo | 48 | ||||
| 10/26/2017 | Toledo | 58 | at | Ball State | 17 | |||
| Eastern Michigan | 27 | at | Northern Illinois | 30 | OT | |||
| 10/28/2017 | Buffalo | 20 | at | Akron | 21 | |||
| 10/31/2017 | Bowling Green | 44 | at | Kent State | 16 | |||
| Miami-Ohio | 28 | at | Ohio | 45 | ||||
| 11/1/2017 | Central Michigan | 35 | at | Western Michigan | 28 | |||
| 11/2/2017 | Ball State | 14 | at | Eastern Michigan | 56 | |||
| Northern Illinois | 17 | at | Toledo | 27 | ||||
| 11/7/2017 | Bowling Green | 28 | at | Buffalo | 38 | |||
| Akron | 14 | at | Miami-Ohio | 24 | ||||
| 11/8/2017 | Eastern Michigan | 30 | at | Central Michigan | 42 | |||
| Toledo | 10 | at | Ohio | 38 | ||||
| Kent State | 20 | at | Western Michigan | 48 | ||||
| 11/9/2017 | Ball State | 17 | at | Northern Illinois | 63 | |||
| 11/14/2017 | Ohio | 34 | at | Akron | 37 | |||
| Central Michigan | 42 | at | Kent State | 23 | ||||
| 11/15/2017 | Toledo | 66 | at | Bowling Green | 37 | |||
| Eastern Michigan | 27 | at | Miami-Ohio | 24 | ||||
| Western Michigan | 31 | at | Northern Illinois | 35 | ||||
| 11/16/2017 | Buffalo | 40 | at | Ball State | 24 | |||
| 11/21/2017 | Kent State | 14 | at | Akron | 24 | |||
| Miami-Ohio | 28 | at | Ball State | 7 | ||||
| Bowling Green | 31 | at | Eastern Michigan | 34 | ||||
| 11/24/2017 | Ohio | 24 | at | Buffalo | 31 | |||
| Northern Illinois | 24 | at | Central Michigan | 31 | ||||
| Western Michigan | 10 | at | Toledo | 37 | ||||
| 12/2/2017 | Akron | 28 | vs | Toledo | 45 | MAC Championship (Detroit MI) | ||
| 12/19/2017 | Akron | 3 | vs | Florida Atlantic | 50 | Boca Raton Bowl (Boca Raton FL) | vs CUSA | |
| 12/22/2017 | UAB | 6 | vs | Ohio | 41 | Bahamas Bowl (Nassau NP) | vs CUSA | |
| Central Michigan | 14 | vs | Wyoming | 37 | Famous Idaho Potato Bowl (Boise ID) | vs MW | ||
| 12/23/2017 | Appalachian State | 34 | vs | Toledo | 0 | Dollar General Bowl (Mobile AL) | vs SBC | |
| 12/26/2017 | Duke | 36 | vs | Northern Illinois | 14 | Quick Lane Bowl (Detroit MI) | vs ACC |