| 8/26/2017 | Hawaii (3-9) | 38 | at | Massachusetts | 35 | MW | ||
| 9/2/2017 | Massachusetts | 28 | at | Coastal Carolina (3-9) | 38 | at SBC | ||
| 9/9/2017 | Old Dominion (5-7) | 17 | at | Massachusetts | 7 | CUSA | ||
| 9/15/2017 | Massachusetts | 21 | at | Temple (7-6) | 29 | at AAC | ||
| 9/23/2017 | Massachusetts | 13 | at | Tennessee (4-8) | 17 | at SEC | ||
| 9/30/2017 | Ohio (9-4) | 58 | at | Massachusetts | 50 | MAC | ||
| 10/14/2017 | Massachusetts | at | South Florida (10-2) | Cancelled | at AAC | |||
| 10/21/2017 | Georgia Southern (2-10) | 20 | at | Massachusetts | 55 | SBC | ||
| 10/28/2017 | Appalachian State (9-4) | 27 | at | Massachusetts | 30 | SBC | ||
| 11/4/2017 | Massachusetts | 23 | at | Mississippi State (9-4) | 34 | at SEC | ||
| 11/11/2017 | Maine (4-6) | 31 | vs | Massachusetts | 44 | Boston MA | CAAF (1AA) | |
| 11/18/2017 | Massachusetts | 16 | at | BYU (4-9,0-1) | 10 | |||
| 12/2/2017 | Massachusetts | 45 | at | Florida Intl (8-5) | 63 | at CUSA |
| vs Massachusetts | vs Other Opponents | Massachusetts compared to OOs | |
| Record: | 8-4 | 69-79 | |
| Points Scored: | 31.83 | 26.05 | -5.78 |
| Points Allowed: | 30.58 | 26.72 | 3.86 |
| Margin: | 1.25 | -0.67 | -1.92 |
| Total Points: | 62.41 | 52.77 | 9.64 |