| 9/2/2017 | Bowling Green (2-10) | 10 | at | Michigan State | 35 | MAC | ||
| 9/9/2017 | Western Michigan (6-6) | 14 | at | Michigan State | 28 | MAC | ||
| 9/23/2017 | Notre Dame (10-3) | 38 | at | Michigan State | 18 | ND | ||
| 9/30/2017 | Iowa (8-5,4-5) | 10 | at | Michigan State | 17 | |||
| 10/7/2017 | Michigan State | 14 | at | Michigan (8-5,5-4) | 10 | |||
| 10/14/2017 | Michigan State | 30 | at | Minnesota (5-7,2-7) | 27 | |||
| 10/21/2017 | Indiana (5-7,2-7) | 9 | at | Michigan State | 17 | |||
| 10/28/2017 | Michigan State | 31 | at | Northwestern (10-3,7-2) | 39 | 3OT | ||
| 11/4/2017 | Penn State (11-2,7-2) | 24 | at | Michigan State | 27 | |||
| 11/11/2017 | Michigan State | 3 | at | Ohio State (12-2,9-1) | 48 | |||
| 11/18/2017 | Maryland (4-8,2-7) | 7 | at | Michigan State | 17 | |||
| 11/25/2017 | Michigan State | 40 | at | Rutgers (4-8,3-6) | 7 | |||
| 12/28/2017 | Washington State (9-4) | 17 | vs | Michigan State | 42 | Holiday Bowl (San Diego) | P12 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 3-10 | 91-60 | |
| Points Scored: | 20.00 | 30.25 | 10.25 |
| Points Allowed: | 24.54 | 24.55 | -0.01 |
| Margin: | -4.54 | 5.70 | 10.24 |
| Total Points: | 44.54 | 54.80 | -10.26 |