| 9/2/2017 | Nevada (3-9) | 20 | at | Northwestern | 31 | MW | ||
| 9/9/2017 | Northwestern | 17 | at | Duke (7-6) | 41 | at ACC | ||
| 9/16/2017 | Bowling Green (2-10) | 7 | at | Northwestern | 49 | MAC | ||
| 9/30/2017 | Northwestern | 24 | at | Wisconsin (13-1,9-1) | 33 | |||
| 10/7/2017 | Penn State (11-2,7-2) | 31 | at | Northwestern | 7 | |||
| 10/14/2017 | Northwestern | 37 | at | Maryland (4-8,2-7) | 21 | |||
| 10/21/2017 | Iowa (8-5,4-5) | 10 | at | Northwestern | 17 | |||
| 10/28/2017 | Michigan State (10-3,7-2) | 31 | at | Northwestern | 39 | 3OT | ||
| 11/4/2017 | Northwestern | 31 | at | Nebraska (4-8,3-6) | 24 | OT | ||
| 11/11/2017 | Purdue (7-6,4-5) | 13 | at | Northwestern | 23 | |||
| 11/18/2017 | Minnesota (5-7,2-7) | 0 | at | Northwestern | 39 | |||
| 11/25/2017 | Northwestern | 42 | at | Illinois (2-10,0-9) | 7 | |||
| 12/29/2017 | Kentucky (7-6) | 23 | vs | Northwestern | 24 | Music City Bowl (Nashville TN) | SEC |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 3-10 | 80-71 | |
| Points Scored: | 20.08 | 27.33 | 7.25 |
| Points Allowed: | 29.23 | 25.44 | 3.79 |
| Margin: | -9.15 | 1.89 | 11.04 |
| Total Points: | 49.31 | 52.77 | -3.46 |