| 9/2/2017 | Akron (7-7) | 0 | at | Penn State | 52 | MAC | ||
| 9/9/2017 | Pittsburgh (5-7) | 14 | at | Penn State | 33 | ACC | ||
| 9/16/2017 | Georgia State (7-5) | 0 | at | Penn State | 56 | SBC | ||
| 9/23/2017 | Penn State | 21 | at | Iowa (8-5,4-5) | 19 | |||
| 9/30/2017 | Indiana (5-7,2-7) | 14 | at | Penn State | 45 | |||
| 10/7/2017 | Penn State | 31 | at | Northwestern (10-3,7-2) | 7 | |||
| 10/21/2017 | Michigan (8-5,5-4) | 13 | at | Penn State | 42 | |||
| 10/28/2017 | Penn State | 38 | at | Ohio State (12-2,9-1) | 39 | |||
| 11/4/2017 | Penn State | 24 | at | Michigan State (10-3,7-2) | 27 | |||
| 11/11/2017 | Rutgers (4-8,3-6) | 6 | at | Penn State | 35 | |||
| 11/18/2017 | Nebraska (4-8,3-6) | 44 | at | Penn State | 56 | |||
| 11/25/2017 | Penn State | 66 | at | Maryland (4-8,2-7) | 3 | |||
| 12/30/2017 | Washington (10-3) | 28 | vs | Penn State | 35 | Fiesta Bowl (Glendale AZ) | P12 |
| vs Penn State | vs Other Opponents | Penn State compared to OOs | |
| Record: | 2-11 | 92-60 | |
| Points Scored: | 16.46 | 27.66 | 11.20 |
| Points Allowed: | 41.08 | 23.03 | 18.05 |
| Margin: | -24.62 | 4.63 | 29.25 |
| Total Points: | 57.54 | 50.69 | 6.85 |