| 8/31/2017 | Presbyterian | 7 | at | Wake Forest | 51 | BigS (1AA) | ||
| 9/1/2017 | Boston College | 23 | at | Northern Illinois | 20 | @ MAC | ||
| Central Conn | 7 | at | Syracuse | 50 | NE (1AA) | |||
| 9/2/2017 | Florida State | 7 | vs | Alabama | 24 | Atlanta GA | vs SEC | |
| Kent State | 3 | at | Clemson | 56 | MAC | |||
| North Carolina Central | 7 | at | Duke | 60 | MEAC (1AA) | |||
| Bethune-Cookman | 13 | at | Miami-Florida | 41 | MEAC (1AA) | |||
| California | 35 | at | North Carolina | 30 | P12 | |||
| Youngstown State | 21 | at | Pittsburgh | 28 | OT | MVC (1AA) | ||
| Louisville | 35 | vs | Purdue | 28 | Indianapolis IN | vs B10 | ||
| North Carolina State | 28 | vs | South Carolina | 35 | Charlotte NC | vs SEC | ||
| William & Mary | 10 | at | Virginia | 28 | CAAF (1AA) | |||
| 9/3/2017 | West Virginia | 24 | vs | Virginia Tech | 31 | Landover MD | vs B12 | |
| 9/4/2017 | Tennessee | 42 | at | Georgia Tech | 41 | 2OT | SEC | |
| 9/9/2017 | Miami-Florida | vs | Arkansas State | Cancelled WX | vs SBC | |||
| Wake Forest | 34 | at | Boston College | 10 | ||||
| Auburn | 6 | at | Clemson | 14 | SEC | |||
| Northwestern | 17 | at | Duke | 41 | B10 | |||
| UL Monroe | at | Florida State | Cancelled WX | SBC | ||||
| Jacksonville State | 10 | at | Georgia Tech | 37 | OVC (1AA) | |||
| Louisville | 47 | at | North Carolina | 35 | ||||
| Marshall | 20 | at | North Carolina State | 37 | CUSA | |||
| Pittsburgh | 14 | at | Penn State | 33 | @ B10 | |||
| Middle Tenn State | 30 | at | Syracuse | 23 | CUSA | |||
| Indiana | 34 | at | Virginia | 17 | B10 | |||
| Delaware | 0 | at | Virginia Tech | 27 | CAAF (1AA) | |||
| 9/16/2017 | Notre Dame | 49 | at | Boston College | 20 | ND | ||
| Georgia Tech | vs | UCF | Cancelled WX | vs AAC | ||||
| Baylor | 20 | at | Duke | 34 | B12 | |||
| Virginia Tech | 64 | at | East Carolina | 17 | @ AAC | |||
| Clemson | 47 | at | Louisville | 21 | ||||
| Furman | 16 | at | North Carolina State | 49 | SoCon (1AA) | |||
| North Carolina | 53 | at | Old Dominion | 23 | @ CUSA | |||
| Oklahoma State | 59 | at | Pittsburgh | 21 | B12 | |||
| Central Michigan | 17 | at | Syracuse | 41 | MAC | |||
| Connecticut | 18 | at | Virginia | 38 | AAC | |||
| Utah State | 10 | at | Wake Forest | 46 | MW | |||
| 9/22/2017 | Virginia | 42 | at | Boise State | 23 | @ MW | ||
| 9/23/2017 | Wake Forest | 20 | at | Appalachian State | 19 | @ SBC | ||
| Boston College | 7 | at | Clemson | 34 | ||||
| North Carolina State | 27 | at | Florida State | 21 | ||||
| Pittsburgh | 17 | at | Georgia Tech | 35 | ||||
| Kent State | 3 | at | Louisville | 42 | MAC | |||
| Syracuse | 26 | at | LSU | 35 | @ SEC | |||
| Toledo | 30 | at | Miami-Florida | 52 | MAC | |||
| Duke | 27 | at | North Carolina | 17 | ||||
| Old Dominion | 0 | at | Virginia Tech | 38 | CUSA | |||
| 9/29/2017 | Miami-Florida | 31 | at | Duke | 6 | |||
| 9/30/2017 | Central Michigan | 8 | at | Boston College | 28 | MAC | ||
| North Carolina | 7 | at | Georgia Tech | 33 | ||||
| Murray State | 10 | at | Louisville | 55 | OVC (1AA) | |||
| Syracuse | 25 | at | North Carolina State | 33 | ||||
| Rice | 10 | at | Pittsburgh | 42 | CUSA | |||
| Clemson | 31 | at | Virginia Tech | 17 | ||||
| Florida State | 26 | at | Wake Forest | 19 | ||||
| 10/5/2017 | Louisville | 25 | at | North Carolina State | 39 | |||
| 10/7/2017 | Virginia Tech | 23 | at | Boston College | 10 | |||
| Wake Forest | 14 | at | Clemson | 28 | ||||
| Miami-Florida | 24 | at | Florida State | 20 | ||||
| Notre Dame | 33 | at | North Carolina | 10 | ND | |||
| Pittsburgh | 24 | at | Syracuse | 27 | ||||
| Duke | 21 | at | Virginia | 28 | ||||
| 10/13/2017 | Clemson | 24 | at | Syracuse | 27 | |||
| 10/14/2017 | Florida State | 17 | at | Duke | 10 | |||
| Boston College | 45 | at | Louisville | 42 | ||||
| Georgia Tech | 24 | at | Miami-Florida | 25 | ||||
| Virginia | 20 | at | North Carolina | 14 | ||||
| North Carolina State | 35 | at | Pittsburgh | 17 | ||||
| 10/21/2017 | Pittsburgh | 24 | at | Duke | 17 | |||
| Louisville | 31 | at | Florida State | 28 | ||||
| Wake Forest | 24 | at | Georgia Tech | 38 | ||||
| Syracuse | 19 | at | Miami-Florida | 27 | ||||
| Boston College | 41 | at | Virginia | 10 | ||||
| North Carolina | 7 | at | Virginia Tech | 59 | ||||
| 10/27/2017 | Florida State | 3 | at | Boston College | 35 | |||
| 10/28/2017 | Georgia Tech | 10 | at | Clemson | 24 | |||
| Miami-Florida | 24 | at | North Carolina | 19 | ||||
| North Carolina State | 14 | at | Notre Dame | 35 | @ ND | |||
| Virginia | 14 | at | Pittsburgh | 31 | ||||
| Duke | 3 | at | Virginia Tech | 24 | ||||
| Louisville | 32 | at | Wake Forest | 42 | ||||
| 11/4/2017 | Syracuse | 24 | at | Florida State | 27 | |||
| Virginia Tech | 10 | at | Miami-Florida | 28 | ||||
| Clemson | 38 | at | North Carolina State | 31 | ||||
| Wake Forest | 37 | at | Notre Dame | 48 | @ ND | |||
| Georgia Tech | 36 | at | Virginia | 40 | ||||
| 11/9/2017 | North Carolina | 34 | at | Pittsburgh | 31 | |||
| 11/11/2017 | Duke | 16 | at | Army | 21 | @ Ind | ||
| North Carolina State | 17 | at | Boston College | 14 | ||||
| Florida State | 14 | at | Clemson | 31 | ||||
| Virginia Tech | 22 | at | Georgia Tech | 28 | ||||
| Virginia | 21 | at | Louisville | 38 | ||||
| Notre Dame | 8 | at | Miami-Florida | 41 | ND | |||
| Wake Forest | 64 | at | Syracuse | 43 | ||||
| 11/18/2017 | The Citadel | 3 | at | Clemson | 61 | SoCon (1AA) | ||
| Boston College | 39 | vs | Connecticut | 16 | Boston MA | vs AAC | ||
| Georgia Tech | 20 | at | Duke | 43 | ||||
| Delaware State | 6 | at | Florida State | 77 | MEAC (1AA) | |||
| Syracuse | 10 | at | Louisville | 56 | ||||
| Virginia | 28 | at | Miami-Florida | 44 | ||||
| Western Carolina | 10 | at | North Carolina | 65 | SoCon (1AA) | |||
| Pittsburgh | 14 | at | Virginia Tech | 20 | ||||
| North Carolina State | 24 | at | Wake Forest | 30 | ||||
| 11/24/2017 | Miami-Florida | 14 | at | Pittsburgh | 24 | |||
| Virginia Tech | 10 | at | Virginia | 0 | ||||
| 11/25/2017 | Florida State | 38 | at | Florida | 22 | @ SEC | ||
| Georgia | 38 | at | Georgia Tech | 7 | SEC | |||
| Louisville | 44 | at | Kentucky | 17 | @ SEC | |||
| North Carolina | 21 | at | North Carolina State | 33 | ||||
| Clemson | 34 | at | South Carolina | 10 | @ SEC | |||
| Boston College | 42 | at | Syracuse | 14 | ||||
| Duke | 31 | at | Wake Forest | 23 | ||||
| 12/2/2017 | Miami-Florida | 3 | vs | Clemson | 38 | ACC Championhship (Charlotte NC) | ||
| UL Monroe | 10 | at | Florida State | 42 | SBC | |||
| 12/26/2017 | Duke | 36 | vs | Northern Illinois | 14 | Quick Lane Bowl (Detroit MI) | vs MAC | |
| 12/27/2017 | Iowa | 27 | vs | Boston College | 20 | Pinstripe Bowl (New York NY) | vs B10 | |
| Southern Miss | 13 | vs | Florida State | 42 | Independence Bowl (Shreveport LA) | vs CUSA | ||
| 12/28/2017 | Virginia | 7 | vs | Navy | 49 | Military Bowl (Annapolis TX) | vs AAC | |
| Virginia Tech | 21 | vs | Oklahoma State | 30 | Camping World Bowl (Orlando FL) | vs B12 | ||
| 12/29/2017 | North Carolina State | 52 | vs | Arizona State | 31 | Sun Bowl (El Paso TX) | vs P12 | |
| Wake Forest | 55 | vs | Texas A&M | 52 | Belk Bowl (Charlotte NC) | vs SEC | ||
| 12/30/2017 | Wisconsin | 34 | vs | Miami-Florida | 24 | Orange Bowl (Miami FL) | vs B10 | |
| Louisville | 27 | vs | Mississippi State | 31 | Taxslayer Bowl (Jacksonville FL) | vs SEC | ||
| 1/1/2018 | Alabama | 24 | vs | Clemson | 6 | Sugar Bowl (New Orleans LA) | vs SEC |