| 9/2/2017 | Charleston Southern (6-5) | 0 | at | Mississippi State | 49 | BigS (1AA) | ||
| 9/9/2017 | Mississippi State | 57 | at | Louisiana Tech (7-6) | 21 | at CUSA | ||
| 9/16/2017 | LSU (9-4,6-2) | 7 | at | Mississippi State | 37 | |||
| 9/23/2017 | Mississippi State | 3 | at | Georgia (13-2,8-2) | 31 | |||
| 9/30/2017 | Mississippi State | 10 | at | Auburn (10-4,7-2) | 49 | |||
| 10/14/2017 | BYU (4-9) | 10 | at | Mississippi State | 35 | Ind | ||
| 10/21/2017 | Kentucky (7-6,4-4) | 7 | at | Mississippi State | 45 | |||
| 10/28/2017 | Mississippi State | 35 | at | Texas A&M (7-6,4-4) | 14 | |||
| 11/4/2017 | Massachusetts (4-8) | 23 | at | Mississippi State | 34 | Ind | ||
| 11/11/2017 | Alabama (13-1,8-1) | 31 | at | Mississippi State | 24 | |||
| 11/18/2017 | Mississippi State | 28 | at | Arkansas (4-8,1-7) | 21 | |||
| 11/23/2017 | Mississippi (6-6,3-5) | 31 | at | Mississippi State | 28 | |||
| 12/30/2017 | Louisville (8-5) | 27 | vs | Mississippi State | 31 | Taxslayer Bowl (Jacksonville FL) | ACC |
| vs Mississippi State | vs Other Opponents | Mississippi State compared to OOs | |
| Record: | 4-9 | 94-61 | |
| Points Scored: | 20.92 | 31.17 | 10.25 |
| Points Allowed: | 32.00 | 24.03 | 7.97 |
| Margin: | -11.08 | 7.14 | 18.22 |
| Total Points: | 52.92 | 55.20 | -2.28 |