| 9/2/2017 | Kentucky (7-6) | 24 | at | Southern Miss | 17 | SEC | ||
| 9/9/2017 | Southern (7-4) | 0 | at | Southern Miss | 45 | SWAC (1AA) | ||
| 9/16/2017 | Southern Miss | 28 | at | UL Monroe (4-8) | 17 | at SBC | ||
| 9/30/2017 | North Texas (9-5,7-2) | 43 | at | Southern Miss | 28 | |||
| 10/7/2017 | Southern Miss | 31 | at | Texas-San Antonio (6-5,3-5) | 29 | |||
| 10/14/2017 | UTEP (0-12,0-8) | 0 | at | Southern Miss | 24 | |||
| 10/21/2017 | Southern Miss | 34 | at | Louisiana Tech (7-6,4-4) | 27 | 2OT | ||
| 10/28/2017 | UAB (8-5,6-2) | 30 | at | Southern Miss | 12 | |||
| 11/4/2017 | Southern Miss | 10 | at | Tennessee (4-8) | 24 | at SEC | ||
| 11/11/2017 | Southern Miss | 43 | at | Rice (1-11,1-7) | 34 | |||
| 11/18/2017 | UNC-Charlotte (1-11,1-7) | 21 | at | Southern Miss | 66 | |||
| 11/25/2017 | Southern Miss | 28 | at | Marshall (8-5,4-4) | 27 | |||
| 12/27/2017 | Southern Miss | 13 | vs | Florida State (7-6) | 42 | Independence Bowl (Shreveport LA) | vs ACC |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 5-8 | 64-84 | |
| Points Scored: | 24.46 | 24.92 | 0.46 |
| Points Allowed: | 29.15 | 28.86 | 0.29 |
| Margin: | -4.69 | -3.94 | 0.75 |
| Total Points: | 53.61 | 53.78 | -0.17 |