| 8/31/2017 | Tulsa (2-10) | 24 | at | Oklahoma State | 59 | AAC | ||
| 9/8/2017 | Oklahoma State | 44 | at | South Alabama (4-8) | 7 | at SBC | ||
| 9/16/2017 | Oklahoma State | 59 | at | Pittsburgh (5-7) | 21 | at ACC | ||
| 9/23/2017 | TCU (11-3,7-3) | 44 | at | Oklahoma State | 31 | |||
| 9/30/2017 | Oklahoma State | 41 | at | Texas Tech (6-7,3-6) | 34 | |||
| 10/14/2017 | Baylor (1-11,1-8) | 16 | at | Oklahoma State | 59 | |||
| 10/21/2017 | Oklahoma State | 13 | at | Texas (7-6,5-4) | 10 | OT | ||
| 10/28/2017 | Oklahoma State | 50 | at | West Virginia (7-6,5-4) | 39 | |||
| 11/4/2017 | Oklahoma (12-2,9-1) | 62 | at | Oklahoma State | 52 | |||
| 11/11/2017 | Oklahoma State | 49 | at | Iowa State (8-5,5-4) | 42 | |||
| 11/18/2017 | Kansas State (8-5,5-4) | 45 | at | Oklahoma State | 40 | |||
| 11/25/2017 | Kansas (1-11,0-9) | 17 | at | Oklahoma State | 58 | |||
| 12/28/2017 | Virginia Tech (9-4) | 21 | vs | Oklahoma State | 30 | Camping World Bowl (Orlando FL) | ACC |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 3-10 | 78-75 | |
| Points Scored: | 29.38 | 29.78 | 0.40 |
| Points Allowed: | 45.00 | 26.10 | 18.90 |
| Margin: | -15.62 | 3.68 | 19.30 |
| Total Points: | 74.38 | 55.88 | 18.50 |