| 9/3/2016 | Eastern Kentucky (3-8) | 24 | at | Purdue | 45 | OVC (1AA) | ||
| 9/10/2016 | Cincinnati (4-8) | 38 | at | Purdue | 20 | AAC | ||
| 9/24/2016 | Nevada (5-7) | 14 | at | Purdue | 24 | MW | ||
| 10/1/2016 | Purdue | 7 | at | Maryland (6-7,3-6) | 50 | |||
| 10/8/2016 | Purdue | 34 | at | Illinois (3-9,2-7) | 31 | OT | ||
| 10/15/2016 | Iowa (8-5,6-3) | 49 | at | Purdue | 35 | |||
| 10/22/2016 | Purdue | 14 | at | Nebraska (9-4,6-3) | 27 | |||
| 10/29/2016 | Penn State (11-3,9-1) | 62 | at | Purdue | 24 | |||
| 11/5/2016 | Purdue | 31 | at | Minnesota (9-4,5-4) | 44 | |||
| 11/12/2016 | Northwestern (7-6,5-4) | 45 | at | Purdue | 17 | |||
| 11/19/2016 | Wisconsin (11-3,7-3) | 49 | at | Purdue | 20 | |||
| 11/26/2016 | Purdue | 24 | at | Indiana (6-7,4-5) | 26 |
| vs Purdue | vs Other Opponents | Purdue compared to OOs | |
| Record: | 9-3 | 73-68 | |
| Points Scored: | 38.25 | 25.40 | -12.85 |
| Points Allowed: | 24.58 | 25.10 | -0.52 |
| Margin: | 13.67 | 0.30 | -13.37 |
| Total Points: | 62.83 | 50.50 | 12.33 |