| 9/1/2016 | Oregon State (4-8) | 23 | at | Minnesota | 30 | P12 | ||
| 9/10/2016 | Indiana State (4-7) | 28 | at | Minnesota | 58 | MVC (1AA) | ||
| 9/24/2016 | Colorado State (7-6) | 24 | at | Minnesota | 31 | MW | ||
| 10/1/2016 | Minnesota | 26 | at | Penn State (11-3,9-1) | 29 | OT | ||
| 10/8/2016 | Iowa (8-5,6-3) | 14 | at | Minnesota | 7 | |||
| 10/15/2016 | Minnesota | 31 | at | Maryland (6-7,3-6) | 10 | |||
| 10/22/2016 | Rutgers (2-10,0-9) | 32 | at | Minnesota | 34 | |||
| 10/29/2016 | Minnesota | 40 | at | Illinois (3-9,2-7) | 17 | |||
| 11/5/2016 | Purdue (3-9,1-8) | 31 | at | Minnesota | 44 | |||
| 11/12/2016 | Minnesota | 17 | at | Nebraska (9-4,6-3) | 24 | |||
| 11/19/2016 | Northwestern (7-6,5-4) | 12 | at | Minnesota | 29 | |||
| 11/26/2016 | Minnesota | 17 | at | Wisconsin (11-3,7-3) | 31 | |||
| 12/27/2016 | Minnesota | 17 | vs | Washington State (8-5) | 12 | Holiday Bowl (San Diego CA) | vs P12 |
| vs Minnesota | vs Other Opponents | Minnesota compared to OOs | |
| Record: | 4-9 | 79-73 | |
| Points Scored: | 22.08 | 27.89 | 5.81 |
| Points Allowed: | 29.31 | 27.48 | 1.83 |
| Margin: | -7.23 | 0.41 | 7.64 |
| Total Points: | 51.39 | 55.37 | -3.98 |