| 9/2/2016 | Furman (3-8) | 13 | at | Michigan State | 28 | SoCon (1AA) | ||
| 9/17/2016 | Michigan State | 36 | at | Notre Dame (4-8) | 28 | at ND | ||
| 9/24/2016 | Wisconsin (11-3,7-3) | 30 | at | Michigan State | 6 | |||
| 10/1/2016 | Michigan State | 21 | at | Indiana (6-7,4-5) | 24 | OT | ||
| 10/8/2016 | BYU (9-4) | 31 | at | Michigan State | 14 | Ind | ||
| 10/15/2016 | Northwestern (7-6,5-4) | 54 | at | Michigan State | 40 | |||
| 10/22/2016 | Michigan State | 17 | at | Maryland (6-7,3-6) | 28 | |||
| 10/29/2016 | Michigan (10-3,7-2) | 32 | at | Michigan State | 23 | |||
| 11/5/2016 | Michigan State | 27 | at | Illinois (3-9,2-7) | 31 | |||
| 11/12/2016 | Rutgers (2-10,0-9) | 0 | at | Michigan State | 49 | |||
| 11/19/2016 | Ohio State (11-2,8-1) | 17 | at | Michigan State | 16 | |||
| 11/26/2016 | Michigan State | 12 | at | Penn State (11-3,9-1) | 45 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 9-3 | 74-67 | |
| Points Scored: | 27.75 | 29.18 | 1.43 |
| Points Allowed: | 24.08 | 24.22 | -0.14 |
| Margin: | 3.67 | 4.96 | 1.29 |
| Total Points: | 51.83 | 53.40 | -1.57 |