| Thursday, 27 Nov 2008 | |||||||
| Tuskegee (D2) | 13 | @ | Alabama St | 17 | |||
| B12 | Texas A&M | 9 | @ | #2 Texas | 49 | ||
| Friday, 28 Nov 2008 | |||||||
| P10 | UCLA | 9 | @ | Arizona St | 34 | ||
| SEC | LSU | 30 | vs | Arkansas | 31 | Little Rock AR | |
| WAC | Fresno St | 10 | @ | #10 Boise St | 61 | ||
| MAC | Kent St | 24 | @ | Buffalo | 21 | ||
| CUSA | UTEP | 21 | @ | East Carolina | 53 | ||
| MAC | Central Michigan | 52 | @ | Eastern Michigan | 56 | ||
| MAC | Ohio U. | 41 | @ | Miami OH | 26 | ||
| SEC | Mississippi St | 0 | @ | Mississippi | 45 | ||
| B12 | Colorado | 31 | @ | Nebraska | 40 | ||
| BigE | West Virginia | 15 | @ | Pittsburgh | 19 | ||
| MAC | Akron | 6 | @ | Temple | 27 | ||
| MAC | Bowling Green | 38 | @ | Toledo | 10 | ||
| Saturday, 29 Nov 2008 | |||||||
| NW Missouri St (D2) | 45 | @ | Abilene Christian (D2) | 36 | |||
| SEC | Auburn | 0 | @ | #5 Alabama | 36 | ||
| South Carolina St | 21 | @ | Appalachian St | 37 | FCS championship round 1 | ||
| SWAC | Texas Southern | 7 | @ | Arkansas-Pine Bluff | 28 | ||
| PSAC | California PA (D2) | 27 | @ | Bloomsburg (D2) | 24 | ||
| ACC | Maryland | 21 | @ | #21 Boston College | 28 | ||
| Weber State | 49 | @ | Cal Poly SLO | 35 | FCS championship round 1 | ||
| CUSA | Alabama-Birmingham | 15 | @ | Central Florida | 0 | ||
| BigE | Syracuse | 10 | @ | #17 Cincinnati | 30 | ||
| South Carolina | 14 | @ | Clemson | 31 | |||
| Curry (D3) | 0 | @ | Cortland St (D3) | 42 | |||
| GSC | North Alabama (D2) | 55 | @ | Delta St (D2) | 34 | ||
| ACC | North Carolina | 28 | @ | Duke | 20 | ||
| SBC | Florida Int'l | 50 | vs | Florida Atlantic | 57 | OT | Miami FL |
| #3 Florida | 45 | @ | #20 Florida St | 15 | |||
| #23 Georgia Tech | 45 | @ | #12 Georgia | 42 | |||
| Minnesota-Duluth (D2) | 19 | @ | Grand Valley St (D2) | 13 | |||
| Washington St | 10 | @ | Hawaii | 24 | |||
| Wofford | 35 | @ | James Madison | 38 | FCS championship round 1 | ||
| WAC | Nevada | 35 | @ | Louisiana Tech | 31 | ||
| CUSA | Tulsa | 38 | @ | Marshall | 35 | ||
| Wesley (D3) | 14 | @ | Mary Hardin-Baylor (D3) | 46 | |||
| CUSA | Tulane | 6 | @ | Memphis | 45 | ||
| Wash & Jeff (D3) | 35 | @ | Millsaps (D3) | 20 | |||
| B12 | Kansas | 40 | vs | #13 Missouri | 37 | Kansas City MO | |
| Wartburg (D3) | 30 | @ | Monmouth IL (D3) | 28 | |||
| Texas St-San Marcos | 13 | @ | Montana | 31 | FCS championship round 1 | ||
| Lindenwood (NAIA) | 34 | @ | Morningside (NAIA) | 31 | |||
| Hobart (D3) | 7 | @ | Mount Union (D3) | 42 | |||
| ACC | Miami FL | 28 | @ | North Carolina St | 38 | ||
| Franklin (D3) | 38 | @ | North Central (D3) | 28 | |||
| SBC | Arkansas St | 33 | @ | North Texas | 28 | ||
| Maine | 15 | @ | Northern Iowa | 40 | FCS championship round 1 | ||
| B12 | #3 Oklahoma | 61 | @ | #13 Oklahoma St | 41 | ||
| P10 | Oregon | 65 | @ | #16 Oregon St | 38 | ||
| CUSA | Houston | 42 | @ | Rice | 56 | ||
| Eastern Kentucky | 10 | @ | Richmond | 38 | FCS championship round 1 | ||
| Langston (D2) | 13 | @ | Sioux Falls (NAIA) | 50 | |||
| CUSA | Southern Miss | 28 | @ | SMU | 12 | ||
| Notre Dame | 3 | @ | #6 Southern Cal | 38 | |||
| New Hampshire | 29 | @ | Southern Illinois | 20 | FCS championship round 1 | ||
| SWAC | Grambling St | 29 | vs | Southern U. | 14 | New Orleans LA | |
| Cumberlands KY (NAIA) | 20 | @ | St Francis IN (NAIA) | 31 | |||
| SEC | Kentucky | 10 | @ | Tennessee | 28 | ||
| B12 | Baylor | 28 | @ | #6 Texas Tech | 35 | ||
| WAC | New Mexico St | 2 | @ | Utah St | 47 | ||
| Colgate | 28 | @ | Villanova | 55 | FCS championship round 1 | ||
| ACC | Virginia | 14 | @ | Virginia Tech | 17 | ||
| Wheaton (D3) | 59 | @ | Wabash (D3) | 28 | |||
| Vanderbilt | 10 | @ | Wake Forest | 23 | |||
| UW-Whitewater (D3) | 30 | @ | Willamette (D3) | 27 | |||
| Wednesday, 3 Dec 2008 | |||||||
| SBC | Middle Tennessee St | 28 | @ | Louisiana-Lafayette | 42 | ||