| 8/28/2010 | Kentucky Christian Knights 7 @ Campbellsville 34 | † |
| 9/4/2010 | Campbellsville 47 @ Union KY Bulldogs 36 | † |
| 9/11/2010 | Campbellsville 21 @ Cumberland TN Bulldogs 33 | † |
| 9/18/2010 | Wisconsin-Whitewater Warhawks 37 @ Campbellsville 7 | |
| 9/25/2010 | Lindsey Wilson Blue Raiders 30 @ Campbellsville 48 | † |
| 10/2/2010 | Campbellsville 62 @ Pikeville Bears 17 | † |
| 10/7/2010 | Georgetown KY Tigers 52 @ Campbellsville 21 | † |
| 10/16/2010 | Campbellsville 28 @ Cumberlands KY Patriots 34 | † |
| 10/23/2010 | Faulkner Eagles 21 @ Campbellsville 22 | † |
| 11/6/2010 | Campbellsville 45 @ Virginia-Wise Highland Cavaliers 42 | † |
| 11/13/2010 | Campbellsville 56 @ West Virginia Tech Golden Bears 35 | † |
| 11/20/2010 | Campbellsville 16 @ North Greenville Crusaders 42 |