| 9/4/2010 | Campbellsville Tigers 47 @ Union KY 36 | † |
| 9/11/2010 | Kentucky Christian Knights 0 @ Union KY 48 | † |
| 9/18/2010 | Union KY 10 @ Wofford Terriers 48 | |
| 9/25/2010 | Virginia-Wise Highland Cavaliers 26 @ Union KY 61 | † |
| 10/2/2010 | Union KY 21 @ Cumberlands KY Patriots 35 | † |
| 10/9/2010 | Bethel TN Wildcats 55 @ Union KY 84 | † |
| 10/16/2010 | Union KY 44 @ Lindsey Wilson Blue Raiders 14 | † |
| 10/23/2010 | Belhaven Blazers 15 @ Union KY 34 | † |
| 10/30/2010 | Union KY 18 @ Cumberland TN Bulldogs 29 | † |
| 11/6/2010 | Union KY 37 @ Shorter Hawks 31 | † |
| 11/13/2010 | Faulkner Eagles 33 @ Union KY 47 | † |