| 9/4/2010 | Notre Dame OH Falcons 14 @ Lindsey Wilson 10 | |
| 9/11/2010 | Southern Virginia Knights 3 @ Lindsey Wilson 44 | |
| 9/18/2010 | Lindsey Wilson 21 @ Belhaven Blazers 49 | † |
| 9/25/2010 | Lindsey Wilson 30 @ Campbellsville Tigers 48 | † |
| 10/2/2010 | Lindsey Wilson 7 @ Cumberland TN Bulldogs 23 | † |
| 10/9/2010 | Pikeville Bears 52 @ Lindsey Wilson 59 | † |
| 10/16/2010 | Union KY Bulldogs 44 @ Lindsey Wilson 14 | † |
| 10/23/2010 | Lindsey Wilson 40 @ Kentucky Christian Knights 37 | † |
| 10/30/2010 | West Virginia Tech Golden Bears 7 @ Lindsey Wilson 9 | † |
| 11/6/2010 | Georgetown KY Tigers 48 @ Lindsey Wilson 0 | † |
| 11/13/2010 | Lindsey Wilson 51 @ Virginia-Wise Highland Cavaliers 22 | † |