| 8/28/2010 | Kentucky Christian 7 @ Campbellsville Tigers 34 | † |
| 9/4/2010 | Kentucky Christian 7 @ Walsh Cavaliers 63 | |
| 9/11/2010 | Kentucky Christian 0 @ Union KY Bulldogs 48 | † |
| 9/18/2010 | Cumberland TN Bulldogs 35 vs Kentucky Christian 6 (Huntington WV) | † |
| 9/30/2010 | Kentucky Christian 12 @ Georgetown KY Tigers 52 | † |
| 10/9/2010 | Virginia-Wise Highland Cavaliers 34 @ Kentucky Christian 31 | † |
| 10/16/2010 | Kentucky Christian 37 @ West Virginia Tech Golden Bears 62 | † |
| 10/23/2010 | Lindsey Wilson Blue Raiders 40 @ Kentucky Christian 37 | † |
| 10/30/2010 | Southern Virginia Knights 45 @ Kentucky Christian 28 | |
| 11/6/2010 | Kentucky Christian 20 @ Bethel TN Wildcats 70 | † |
| 11/14/2010 | Kentucky Christian 14 @ Pikeville Bears 44 | † |