| 9/4/2010 | Adrian Bulldogs 0 @ Wisconsin-Whitewater 35 | |
| 9/11/2010 | Dakota State Trojans 7 @ Wisconsin-Whitewater 70 | |
| 9/18/2010 | Wisconsin-Whitewater 37 @ Campbellsville Tigers 7 | |
| 9/30/2010 | Wisconsin-Whitewater 49 @ Wisconsin-Platteville Pioneers 17 | † |
| 10/9/2010 | Wisconsin-Stout Blue Devils 7 @ Wisconsin-Whitewater 30 | † |
| 10/16/2010 | Wisconsin-Whitewater 45 @ Wisconsin-Eau Claire Blugolds 0 | † |
| 10/23/2010 | Wisconsin-Whitewater 63 @ Wisconsin-River Falls Falcons 14 | † |
| 10/30/2010 | Wisconsin-Stevens Point Pointers 14 @ Wisconsin-Whitewater 27 | † |
| 11/6/2010 | Wisconsin-Whitewater 48 @ Wisconsin-Oshkosh Titans 21 | † |
| 11/13/2010 | Wisconsin-La Crosse Eagles 0 @ Wisconsin-Whitewater 24 | † |
| 11/20/2010 | Franklin Grizzlies 21 @ Wisconsin-Whitewater 52 | |
| 11/27/2010 | Trine Thunder 31 @ Wisconsin-Whitewater 45 | |
| 12/4/2010 | Wisconsin-Whitewater 20 @ North Central Cardinals 10 | |
| 12/11/2010 | Wisconsin-Whitewater 27 @ Wesley Wolverines 7 | |
| 12/18/2010 | Wisconsin-Whitewater 31 vs Mount Union Purple Raiders 21 (Salem VA - Amos Alonzo Stagg Bowl (D3 Championship)) |