| 9/4/2010 | Georgetown KY 20 @ Webber International Warriors 27 | |
| 9/18/2010 | Georgetown KY 58 @ Cumberlands KY Patriots 40 | † |
| 9/25/2010 | Georgetown KY 46 @ Shorter Hawks 47 1OT | † |
| 9/30/2010 | Kentucky Christian Knights 12 @ Georgetown KY 52 | † |
| 10/7/2010 | Georgetown KY 52 @ Campbellsville Tigers 21 | † |
| 10/16/2010 | Pikeville Bears 58 @ Georgetown KY 70 | † |
| 10/23/2010 | Georgetown KY 52 @ West Virginia Tech Golden Bears 16 | † |
| 10/30/2010 | Virginia-Wise Highland Cavaliers 29 @ Georgetown KY 58 | † |
| 11/6/2010 | Georgetown KY 48 @ Lindsey Wilson Blue Raiders 0 | † |
| 11/13/2010 | Belhaven Blazers 19 @ Georgetown KY 24 | † |
| 11/20/2010 | Georgetown KY 24 @ MidAmerica Nazarene Pioneers 27 |